Abstract

Fullerene, a carbon-based material, is being beneficially applied in nanotechnology on a limited but expanding basis. Some advantages of fullerene are its ability to react with nucleophiles and undergo various chemical reactions, such as reduction, oxidation, hydrogenation and halogenation. Some disadvantages of fullerene are its susceptibility to degrade in the presence of light and oxygen and decompose due to a shift from the excited singlet state to an energetically lower triplet state. Also, fullerene’s hydrophobic and aggregate-forming characteristics are significantly challenging in its application in medicine. Nevertheless, fullerene has potential applications in managing neuropathic pain and anaesthesia. The stimulation of specific voltage-gated sodium channels results in pain disorders. Fullerene can block the channel pore, demonstrating fullerene’s potential in managing neuropathic pain. In conjunction with nanorobot technology, fullerene might act as an anaesthetic or analgaesic agent and a nanomaterial for dental robots. Pristine C₆₀ is relatively less toxic than other variants of nanocarbons, and in many instances, shows biocompatibility in humans. However, the manufacturing process of experimental-grade nanocarbon onion-like fullerene materials can be inconsistent (even within the same batch). Thus, performing reliable assessments and reproducible studies of their biological benefits, biocompatibility, and potential toxicity are are problematic

Keywords: Allotrope; Anaesthesia; Analgaesic; Buckyball; Fullerene; Isoform hNa_v1.7

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