Case Report
Volume 7 Issue 1 - 2020
Experience of Malignant Hyperthermia in a COVID-19 Patient During Urgent Surgery for Necrotizing Fasciitis
Andrew R Knapp*, Benjamin Stix, Jennifer Danielsson, Jonathan A Paul and Maya Mikami
Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York, USA
*Corresponding Author: Andrew R Knapp, Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York, USA.
Received: June 10, 2021; Published: June 14, 2021




Abstract

Surgical patients with novel coronavirus disease (COVID-19) add complexity in the perioperative period. We experienced a case of suspected malignant hyperthermia (MH) in a COVID-19 patient with a history of intravenous multi-drug abuse undergoing emergent fasciotomy for necrotizing fasciitis. At the end of the procedure, the patient became hypercarbic, hypotensive, and hyperthermic. Intraoperative differential included rhabdomyolysis, septic shock (secondary to necrotizing fasciitis or possibly COVID-19) versus MH. Dantrolene was given with resolution of hyperthermia and hypercarbia. This may be the first case of MH in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection.

Keywords: Malignant Hyperthermia; COVID-19

References

  1. Rosenberg Henry., et al. “Malignant Hyperthermia”. Orphanet Journal of Rare Diseases 2 (2007): 21.
  2. Litman RS., et al. “Malignant Hyperthermia Susceptibility and Related Diseases”. Anesthesiology 128 (2018): 159-167.
  3. Brady JE., et al. “Prevalence of Malignant Hyperthermia Due to Anesthesia in New York State, 2001-2005”. Anesthesia and Analgesia 4 (2009): 1162-1166.
  4. Neeki MM., et al. “Evaluating the Laboratory Risk Indicator to Differentiate Cellulitis from Necrotizing Fasciitis in the Emergency Department”. West Journal of Emergency Medicine4 (2017): 684-689.
  5. Zucco L., et al. “Perioperative Considerations for the 2019 Novel Coronavirus (Covid-19)”. Anesthesia Patient Safety Foundation (2020).
  6. Larach MG., et al. “A Clinical Grading Scale to Predict Malignant Hyperthermia Susceptibility”. Anesthesiology 80 (1994): 771-779.
  7. Yang L., et al. “The Current Status of Malignant Hyperthermia”. Journal of Biomedical Research2 (2020): 75-85.
  8. Hardy Tom and Whitney Marvin. "794: Viral Infection Triggered Malignant Hyperthermia Episode”. Critical Care Medicine1 (2019): 376.
  9. Molenaar J., et al. “Fever-Induced Recurrent Rhabdomyolysis Due to a Novel Mutation in the Ryanodine Receptor Type 1 Gene”. Journal of Internal Medicine 8 (2014): 819-820.
  10. Goh KJ., et al. “Rapid Progression to Acute Respiratory Distress Syndrome: Review of Current Understanding of Critical Illness from Coronavirus disease 2019 (COVID-19) Infection”. Academy of Medicine Singapore Singapore3 (2020): 108-118.
  11. Felsenstein S., et al. “Covid-19: Immunology and Treatment Options”. Journal of Clinical Immunology 215 (2020): 108448.
  12. Huang C., et al. “Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China”. Lancet10223 (2020): 497-506.
  13. Van Doremalen N., et al. “Aerosol and Surface Stability of Sars-Cov-2 as Compared with Sars-Cov-1”. The New England Journal of Medicine 16 (2020): 1564-1567.
  14. Ti LK., et al. “What We Do When a Covid-19 Patient Needs an Operation: Operating Room Preparation and Guidance”. Canadian Journal of Anesthesia 67 (2020): 756-758.
Citation: Andrew R Knapp., et al. “Experience of Malignant Hyperthermia in a COVID-19 Patient During Urgent Surgery for Necrotizing Fasciitis”. EC Anaesthesia 6.11 (2020): 12-16.

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