Abstract

Butyrate is a metabolite of short chain fatty acid by the gut microbiota in large intestine. Butyrate is main energy source for enterocyte regeneration and modulates the enteric microbial community and contributes to impact on intestinal health and host well-being with its beneficial activity in inflammation and neurological disorders. The gut microbiome has played a crucial role in the multi-directional gut-brain axis that integrates the gut and central nerve system activities, and thus a concept of microbiome-gut-brain axis is emerging. In this review, we describe the putative efficacy of gut butyrate to autism spectrum disorders (ASD) and exhibit a case report of ASD patient with aloe vera juice adjuvant.

Keywords: Immune Modulation; Endophytically Fermented Aloe Butyrate; Microbiome-Gut-Brain Axis; Autism Spectrum Disorders; A Case Report

References

1. Sivaprakasam S., et al. “Short chain fatty acid transfers: Role in colonic homeostasis”. Comprehensive Physiology 8.1 (2017): 299-314.
2. Kang DW., et al. “Microbiota transfer therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study”. Microbiome 5 (2017): 10.
3. Kang DW., et al. “Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota”. Scientific Reports 9 (2019): 5821.
4. Kang DW., et al. “Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders”. Anaerobe 49 (2018): 121-131.
5. Xu M., et al. “Association between gut microbiota and autism spectrum disorder: A systematic review and meta-analysis”. Front Psychiatry 10 (2019): 473. 
6. Adams JB., et al. “Gastrointestinal flora and gastrointestinal status in children with autism: comparisons to typical children and correlation with autism severity”. BMC Gastroenterology 11 (2011): 22. 
7. Coretti L., et al. “Gut microbiota features in young children with autism spectrum disorders”. Frontiers in Microbiology 10 (2019): 920.
8. Sun H., et al. “Autism spectrum disorder is associated with gut microbiota disorder in children”. BMC Pediatrics 19.1 (2019): 516.
9. Rose S., et al. “Mitochondrial dysfunction in the gastrointestinal mucosa of children with autism: A blinded case-control study”. Plos one 12.10 (2017): e0186377. 
10. Rose S., et al. “Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism”. Translational Psychiatry 8 (2018): 42.
11. Anderson G. “Gut dysbiosis dysregulates central and systemic homeostasis via decreased melatonin and suboptimal mitochondria functioning: pathoetiological and pathophysiological implications”. Melatonin Research 2.2 (2019): 70-85.
12. Srikantha P and Mohajeri MH. “The possible role of the microbiota-gut-brain-axis in autism spectrum disorder”. International Journal of Molecular Sciences 20.9 (2019): 2115.
13. Mohajeri MH., et al. “Relationship between the gut microbiome and brain function”. Nutrition Reviews 76 (2018): 481-496.
14. A Yagi., et al. “Short chain fatty acids from fermentation by endophytic bacteria in Aloe vera leaf rind and gel”. Journal of Gastroenterology and Hepatology Research 5.4 (2016): 2122-2124.
15. A Yagi., et al. “Possible prophylaxes of Aloe vera gel ingestion to butyrate metabolism”. Journal of Gastroenterology and Hepatology Research 5.5 (2016): 2158-2164.
16. L Al-Madboly., et al. “Dietary cancer prevention with butyrate fermented by Aloe vera gel endophytic microbiota”. Journal of Gastroenterology and Hepatology Research 6.2 (2017): 2312-2317.
17. Raghavan R., et al. “Fetal and infancy growth pattern, cord and early childhood plasma leptin, and development of autism spectrum disorder in the Boston birth cohort”. Autism Research 11.10 (2018): 1416-1431.
18. Liu S., et al. “Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder”. Scientific Reports (2019).
19. Xiang AH., et al. “Maternal type1 diabetes and risk of autism in offspring”. Journal of the American Medicine Association 320.1 (2018): 89-91. 
20. Xiang AH., et al. “Association of maternal diabetes with autism in offspring”. Journal of the American Medicine Association 313.14 (2015): 1425-1434.
21. Xiang AH., et al. “Hemoglobin A1C levels during pregnancy and risk of autism spectrum disorders in offspring”. Journal of the American Medicine Association (2019).
22. Cordero C., et al. “Maternal diabetes and hypertension disorders in association with autism spectrum disorder”. Autism Research 12.6 (2019): 967-975.
23. Windham GC., et al. “Maternal pre-pregnancy body mass index and gestational weight gain in relation to autism spectrum disorder and other developmental disorders in offspring”. Autism Research 12.2 (2019): 316-327. 
24. Grimald R., et al. “A prebiotic intervention study in children with autism spectrum disorders”. Microbiome 6 (2018): 133.
25. Sharon G., et al. “Human gut microbiota from autism spectrum disorders promotes behavioral symptoms in mice”. Cell 177.6 (2019): 1600-1618.
26. J Ning., et al. “Increased serum levels of macrophage migration inhibitory factor in autism spectrum disorders”. Neuro Toxicology 71 (2019): 1-5. 
27. Enry D., et al. “Host microbiota constantly control maturation and function of microglia in the CNS”. Nature Neuroscience 18.7 (2015): 965-977. 
28. Schulthess J., et al. “The short chain fatty acid butyrate imprints an antimicrobial program in macrophages”. Immunity 50.2 (2019): 432-445.e7. 
29. A Yagi and S Ataka. “Putative prophylaxes of Aloe vera juice with L-arginine to chronic fatigue syndrome”. Journal of Gastroenterology and Hepatology Research 5.2 (2016): 1950-1956.
30. A Yagi and S Ataka. “Possible prophylaxes of Aloe vera juice with CoQ10 to enhance muscle performance”. Journal of Gastroenterology and Hepatology Research 5.3 (2016): 2043-2049. 
31. Hoirisch-Clapauch S and Nardi AE. “Autism spectrum disorders: let’s talk about glucose?”. Translational Psychiatry 9.1 (2019): 51.