Research Article
Volume 4 Issue 2 - 2021
Total Serum Immunoglobulin M in Asymptomatic COVID-19 Seropositive People
Olatunde Olayanju1,2*, Chika Okwor3, Olabisi Bamidele1, Bola Eseile1 and Fabian Edem4
1Chemical Pathology Department, University College Hospital, Ibadan, Nigeria
2Medicine Department, University of Cape Town, Cape Town, South Africa
3Chemical Pathology Department, University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Nigeria
4Immunology Department, University of Ibadan, Ibadan, Nigeria
*Corresponding Author: Olatunde Olayanju, Division of Pulmonology, Department of Medicine, Centre for Lung Infection and Immunity, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town, South Africa.
Received: December 03, 2020; Published: January 30, 2021


Background: Coronavirus has continued to ravage the world with several countries either currently experiencing a second wave of the pandemic or instituting more stringent control measures to forestall further spread. Laboratory testing plays a major role in diagnosing the disease, but the standard diagnostic test is very expensive. Several countries have reduced testing thereby jeopardizing the initial gains of case detection. There is now a need for cheaper and more readily available preliminary testing options to determine who really requires the standard testing especially in low- and middle-income countries.

Method: Serum samples from the pool of asymptomatic participants for COVID-19 testing were obtained. They were divided into two groups which included those who tested positive and those who tested negative. Levels of serum Immunoglobulin M was measured in those samples using ELISA techniques and the values were compared between the two groups to determine if there was a difference.

Result: A total of 83 samples were evaluated for this study. 44 of them were obtained from the COVID-19 positive pool while the remaining 39 were from the COVID-19 negative pool. There was no statistical difference in the age group, gender and occupation between the two groups. The mean (± SD) of serum Immunoglobulin M was 4.11 (± 3.70) µg/ml from the COVID-19 positive pool and 4.53 (± 3.49) µg/ml from the COVID-19 negative pool; there was no statistical difference between the two groups.

Conclusion: This study found no difference in the values of serum Immunoglobulin M between COVID-19 positive sample pool and COVID-19 negative sample pool. This calls for a continued search for other alternative cheaper testing platforms for COVID-19 especially in low- and middle-income countries.


Keywords: COVID-19; IgM; Seropositive; Asymptomatic


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Citation: Olatunde Olayanju.,et al. “Total Serum Immunoglobulin M in Asymptomatic COVID-19 Seropositive People”. EC Clinical and Medical Case Reports 4.2 (2021): 47-52.

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