Research Article
Volume 4 Issue 4 - 2021
Nanoparticle Conjugated Antibody and Crispr-Cas 9 DNA Editing Enumeration Reveals the Possible Vaccination Against Spontaneous “IS::Tn::IS” Based Corona Mutants
Nitosh Kumar Brahma*
Professor, Institute of Genetic Engineering, India
*Corresponding Author: Nitosh Kumar Brahma, Professor, Institute of Genetic Engineering, India.
Received: February 04, 2021; Published: March 17, 2021




Abstract

Global corona pandemic forced scientists worldwide, to search the reason for its spontaneous changes of infective mode, (i.e. the changing sequence of m-RNA (Messenger Ribonucleic acid), that mainly being transmitted by the corona virus membrane coat fusion to lung alveolus cell and cause infection.). In this paper the author attempts to describe, the cause of rapid mutation of m-RNA, that has changed the viral spike protein structures, adhering and fusing nature of corona, to infect host spontaneously and caused global pandemic. To elaborate the camouflaging of corona pandemics, the author has considered the function of transposable element, the jumping gene, illegitimate, spontaneous, recombination mutational problem. The said gene was discovered by Nobel Laureates madam Prof. Barbara Mc Clintock, 1940 in USA on Maize. Later this was studied in microbes by Prof. H. Saedler and Prof. P Starlinger in Germany. “IS::Tn:: IS”DNA (Insertion Sequence Flanked Transposable elements.IS::Tn::IS supports the spontaneous illegitimate recombination of surface spike proteins of corona. Tn in presence of IS (insertion sequence), was studied in DNA and RNA mutations, rearrangements and antibiotic resistance in Escherichia coli K-12 experiments. In addition, the author emphasized the possible development of AAIR (Antiadherent Immune response)in Balb/C mice, imagining the author’s concept of nano-coating, and Crispr/Cas- 9 transposons of Nobel laureates madam(s) Prof. Duodna and Charpentier, 2020, as used in DNA repairing, and is inspired to be used for Corona RNA and to combat corona pandemics. Due to spontaneous DNA mutations, and the morphological change of corona spike proteins disturb the development of stable vaccinations. Corona treatments by nanoparticle, conjugated antibodies (plasma), AAIR and CRISPR-cas-9, DNA editing, perhaps, to be the ultimate solution to prevent corona like respiratory pandemics in future world.

Keywords: Microbes; Corona; Vaccine; Transposons; and Spike (S) Protein

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Citation: Nitosh Kumar Brahma. “Nanoparticle Conjugated Antibody and Crispr-Cas 9 DNA Editing Enumeration Reveals the Possible Vaccination Against Spontaneous “IS::Tn::IS” Based Corona Mutants”. EC Clinical and Medical Case Reports 4.4 (2021): 05-15.

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