Short Communication
Volume 4 Issue 6 - 2021
Enhancing Embryo Survivality by CRISPR/Cas9 Mediated Editing of PTGFS Gene
S Mondal1*, IJ Reddy1, S Nandi1, PSP Gupta1, DN Das2 and D Malakar3
1ICAR-National Institute of Animal Nutrition and Physiology, Adugodi, Bangalore, Karnataka, India
2ICAR-National Dairy Research Institute (SRS), Bangalore, Karnataka, India
3ICAR-National Dairy Research Institute, Karnal, Haryana, India
*Corresponding Author: S Mondal, ICAR-National Institute of Animal Nutrition and Physiology, Adugodi, Bangalore, Karnataka, India.
Received: April 16, 2020; Published: May 28, 2021




Early embryonic mortality is one of the major factors of reproductive failure that causes considerable challenge to the livestock industry [1-11]. Indian livestock economics is seriously affected by embryonic wastages and hence its control is the greatest concern to the scientists and policy makers. It has been observed that more than 40% of the total embryonic mortality occurs between days 8 and 17 of pregnancy in bovine [12]. Embryonic losses are reported to be 20-30% in sheep and more than 70 - 80% of the total embryonic mortality occurs between days 8 and 16 of pregnancy [13]. The survivality of embryo during early embryonic life in mammals is mostly dependent on the concerted events where the uterus and terminally differentiated embryos exchange signals culminating in maternal recognition of pregnancy (MRP) [14]. The major reason for embryonic mortality is failure of cellular and molecular dialogues at embryo-uterine interface [15]. Understanding and unraveling the secrets of implantation, embryo development and reciprocal signaling networks between the embryo and uterus will lead to alleviation of the problems of infertility. The recent advances in molecular biology and biotechnology particularly functional genomics (DNAarrays) allowed identifying embryonic and maternal genes potentially involved in embryo survival. Validation of the functional involvement of genes identified requires extensive in vitro studies before in vivo therapy can be applied.

References

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Citation: S Mondal., et al. “Enhancing Embryo Survivality by CRISPR/Cas9 Mediated Editing of PTGFS Gene”. EC Clinical and Medical Case Reports 4.6 (2021): 37-39.

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