Several researches has reported that diets rich in anthocyanins can prevent metabolic diseases. Obesity is caused by a long-term difference in energy intake and expenditure (i.e. positive energy balance), which leads to a rise in body mass and the accumulation of subcutaneous and visceral fat. Despite the fact that obesity is a risk factor for a variety of diseases, numerous human studies have found that visceral fat, or fat in the viscera, is the fat that is most closely associated to a variety of health problems [1,2]. Insulin resistance (IR) has been associated to a number of metabolic issues, including insulin resistance, non-insulin-dependent diabetes, hypertension, and dyslipidemia. Moreover, the pathophysiology of IR in obesity, as well as the processes that cause it, remain unexplained [3]. Under normal physiological settings, the insulin and glucagon levels of glucose in equilibrium are within a small range. It was assumed that it had been managed. The perception of the presence of a more complicated multihormonal system has shifted in recent years. The metabolism of glucose and lipids are also implicated. Adipokines (leptin, adiponectin, visfatin, resistin, and adipsin) secreted from adipose tissue, as well as GLP-1, ghrelin, and glucose-dependent insulinotropic polypeptide (GIP) secreted from the intestinal tract, all play a role [4].
References
- Finelli C., et al. “Should visceral fat be reduced to increase longevity?” Ageing Research Reviews 4 (2013): 996-1004.
- Finelli C. “Visceral Fat and Diabetes: A Direct Relationship?” EC Diabetes and Metabolic Research3 (2020): 01-02.
- Finelli C. “Metabolic Syndrome and Adipose Tissue: Potential Connections”. EC Endocrinology and Metabolic Research9 (2019): 35-37.
- Tura A., et al. “Glucagon and insulin secretion, insulin clearance, and fasting glucose in GIP receptor and GLP-1 receptor knockout mice”. American Journal of Physiology - Regulatory Integrative and Comparative Physiology 1 (2019): R27-R37.
- Khoo HE., et al. “Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits”. Food and Nutrition Research 1 (2017): 1361779.
- Da Porto A., et al. “Polyphenols Rich Diets and Risk of Type 2 Diabetes”. Nutrients5 (2021): 1445.
- Li A., et al. “Research Advances of Purple Sweet Potato Anthocyanins: Extraction, Identification, Stability, Bioactivity, Application, and Biotransformation”. Molecules21 (2019): 3816.
- Mozos I., et al. “Effects of Anthocyanins on Vascular Health”. Biomolecules6 (2021): 811.
- Yamuangmorn S and Prom-U-Thai C. “The Potential of High-Anthocyanin Purple Rice as a Functional Ingredient in Human Health”. Antioxidants6 (2021): 833.
- Garcia C and Blesso CN. “Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis”. Free Radical Biology and Medicine 172 (2021): 152-166.
- Kozłowska A and Dzierżanowski T. “Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update”. Molecules14 (2021): 4380.
- Berdowska I., et al. “Punicalagin in Cancer Prevention-Via Signaling Pathways Targeting”. Nutrients 8 (2021): 2733.
- Festa J., et al. “Potential Benefits of Berry Anthocyanins on Vascular Function”. Molecular Nutrition and Food Research (2021): e2100170.
- Ockermann P., et al. “A Review of the Properties of Anthocyanins and Their Influence on Factors Affecting Cardiometabolic and Cognitive Health”. Nutrients8 (2021): 2831.
- Kowalska K., et al. “ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction”. Nutrients3 (2021): 885.
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