Mini Review
Volume 5 Issue 2 - 2022
Coronavirus Disease (SARS-CoV-2) and Vascular Dysfunction
Gundu HR Rao*
Emeritus Professor, Laboratory Medicine and Pathology, Director, Thrombosis Research, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA
*Corresponding Author: Gundu HR Rao, Emeritus Professor, Laboratory Medicine and Pathology, Director, Thrombosis Research, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA.
Received: November 22, 2021; Published: January 27, 2022


A novel respiratory virus has developed into a severe killer and has caused unprecedented health and economic crisis worldwide. The standard clinical features of this disease include fever, dry cough, sore throat, headache, fatigue, and breathlessness. Considering that this is a closely related strain of the severe respiratory disease virus, clinicians should make every effort to prevent lung damage and spread of this virus to the vascular system. Age and comorbidities seem to influence the severity of the disease. Odds of death seem to be 7-fold greater for those aged 61 - 80 years; 12-fold higher for those aged 80 years; 24 - 31% greater for those with hypertension, obesity, diabetes, and vascular diseases. We have described this disease as a syndemic disease of cardiometabolic diseases. Because of this syndemic nature, many individuals with metabolic disease risk are developing severe coronavirus disease. Clinical observational studies have shown that individuals with metabolic diseases have compromised vascular and immune systems. This double burden of dysfunctional systems enhances the severity of the coronavirus disease in these COVID-19 patients. Primary prevention by strict adherence to safe public health recommendations and secondary prevention to prevent or reduce viral load at the initial transmission stages were recommended. With the availability of oral antiviral pills, it is possible to prevent the virus from damaging the lungs or the vascular system.

Keywords: Coronavirus Disease; SARS-CoV-2; Vascular Dysfunction


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Citation: Gundu HR Rao. “Coronavirus Disease (SARS-CoV-2) and Vascular Dysfunction”. EC Clinical and Medical Case Reports 5.2 (2022): 83-89.

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