Case Series
Volume 5 Issue 8 - 2022
Beneficial Role of Histone Deacetylase Inhibitor, Butyrate, to Multiple Myeloma: Case Reports
Akira Yagi1*, Megumi Hasegawa2 and Hiroyuki Abe3

1Special Advisor of Japan Aloe Science Association, Professor Emeritus of Fukuyama University, Hiroshima, Japan
2Pharmacist, Kampo Pharmacy Grace-Meg-Salon, Toshima-ku, Tokyo, Japan
3Founder/President of International Society of Personalized Medicine, Chiyoda-ku, Tokyo, Japan

*Corresponding Author: Akira Yagi, Special Advisor of Japan Aloe Science Association, Professor Emeritus of Fukuyama University, Hiroshima, Japan.
Received: July 05, 2022; Published: July 29, 2022


Multiple myeloma (MM) belongs to hematological malignancy that derives pro-survival/ proliferative signals from the bone marrow niche. Butyrate, a class I histone deacetylase inhibitor in MM, reduces the viability of MM cells, induces MM cell apoptosis via transcriptional activation of p21. The author discussed fermented butyrate in aloe vera juice (AVJ) as a potential adjuvant for MM, and in case reports of MM patient we expressed how autologous peripheral blood stem cell (APBST) transplantation therapy, and daratumab, velcade and dexamethasone (Dvd) and thalidomide administration recovered MM and how butyrate fermented in AVJ as an adjuvant prevented MM patient receiving paraneoplastic cerebella degeneration (PCD) treatment.


Keywords: Remission of Multiple Myeloma; APBST-Treatment; Drug Admission; Aloe Vera Gel; Fermented Butyrate; Case Reports


  1. Mithraprabhu S., et al. “Dysregulated class I histone deacetylases are indicators of poor prognosis in multiple myeloma”. Epigenetics 11 (2014): 1511-1520.
  2. Yao R., et al. “Histone deacetylase inhibitor sodium butyrate suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma”. American Journal of Translational Research 11 (2017): 4994-5002.
  3. A Yagi., et al. “Beneficial roles of histone deacetylase inhibitor butyrate to multiple myeloma, acute leukemia and acute myeloid leukemia: case reports”. Journal of Gastroenterology and Hepatology 2 (2020): 3107-3112.
  4. Pianko MJ., et al. “Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition”. Blood Advances 13 (2019): 2040-3044.
  5. Pianko MJ., et al. “Intestinal microbiota composition is associated with minimal residual disease negativity in patients with multiple myeloma”. Blood1 (2018): 3162.
  6. Jian X., et al. “Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen recycling bacteria”. Blood 1 (2019): 688.
  7. Yagi A., et al. “Prophylactic role of Aloe components, butyrate fermented, micrnas, and hyaluronan on Alzheimer’s disease, Parkinson’s disease, and osteoarthritis in knee joints: case reports of aloe vera juice ingestion producing intestinal butyrogenic microbiome and bone regeneration”. Journal of Gastroenterology and Hepatology 1 (2021): 3398-3406.
  8. Cea M., et al. “New insights into the treatment of multiple myeloma with histone deacetylase inhibitors”. Current Pharmaceutical Design 4 (2013): 734-744.
  9. Yuille S., et al. “Human gut bacteria as potential class I histone deacetylase inhibitor in vitro through production of butyric acid and valeric acid”. Plos One (2018).
  10. Nwangwu CA., et al. “Increase of CIK cell efficacy by upregulating cell surface MICA and inhibition of NKG2D ligand shedding in multiple myeloma”. Hematological Oncology 4 (2017): 719-725.
  11. Alkharabsheh O., et al. “The human microbiota in multiple myeloma and proteasome inhibitors”. Acta Haematologica 143 (2020): 118-123.
  12. Harada T., et al. “Histone deacetylase inhibitors in multiple myeloma: from bench to bedside”. International Journal of Hematology 104 (2016): 304-309.
  13. Lu Q and Stappenbeck TS. “Local barriers configure systemic communications between the host and microbiota”. Science 376 (2022): 950-955.
Citation: Akira Yagi., et al. “Beneficial Role of Histone Deacetylase Inhibitor, Butyrate, to Multiple Myeloma: Case Reports”. EC Clinical and Medical Case Reports 5.8 (2022): 70-74.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

March Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the March issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 14, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.