Research Article
Volume 7 Issue 3 - 2020
Association of PAI-1 rs2227631 Variant and Clinical Factors with Recurrent Myocardial Infarction in Patients with Coronary Artery Disease
Vacis Tatarunas1*, Nora Kupstyte-Kristapone1,2,3, Ieva Eitminaviciute1, Remigijus Zaliunas2 and Vaiva Lesauskaite1
1Institute of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania
2Department of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania
3Cardiovascular Center of Republican Hospital of Siauliai, Siauliai, Lithuania
*Corresponding Author: Vacis Tatarunas, Institute of Cardiology of Lithuanian University of Health Sciences, Kaunas, Lithuania.
Received: December 26, 2019; Published: February 13, 2020




Abstract

Background: There is a lack of studies explicating the association between genetic and clinical factors (such as diabetes mellitus) and increased risk of recurrent myocardial infarction (reMI). In this study, the impact of PAI-1 rs2227631 variant and clinical factors on reMI was analyzed in patients hospitalized due to acute coronary syndromes.

Methods and Results: All patients (n = 674) were hospitalized for percutaneous coronary intervention and stent implantation due to acute coronary syndromes (myocardial infarction or unstable angina). A total of 29.7% of the patients were hospitalized with recurrent MI, which was documented in anamnesis. Genotyping of PAI-1 rs2227631 was performed for all study patients. Diabetes and PAI-1 A allele were more frequently found in those patients with reMI who were older than 65 years. Multivariate binary regression analysis revealed that male gender, diabetes and A allele of PAI-1 rs2227631 increased the odds of reMI infarction by 1.764, 1.708 and 3.373 times, respectively. 

Conclusion: Multivariate analysis showed that in aged patients with acute coronary syndromes, the incidence of reMI increased in males, in patients with diabetes and in PAI-1 rs2227631 A allele carriers.

Keywords: Diabetes Mellitus; Recurrent MI; PAI-1 rs2227631

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Citation: Vacis Tatarunas., et al. “Association of PAI-1 rs2227631 Variant and Clinical Factors with Recurrent Myocardial Infarction in Patients with Coronary Artery Disease”. EC Cardiology 7.3 (2020): 01-08.

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