Research Article
Volume 7 Issue 6 - 2020
Complete Atrioventricular Septal Defect: Impact of Down Syndrome on Atrioventricular Valve Morphology and Haemodynamics and Clinical Outcomes
Meryem Haboub*, Abdenasser Drighil and Hanane Mechal
Cardiology Department, Hospital University Ibn Rochd, Casablanca, Morocco
*Corresponding Author: Meryem Haboub, Cardiology Department, Hospital University Ibn Rochd, Casablanca, Morocco.
Received: April 18, 2020; Published: May 14, 2020




Abstract

Background: Other cardiac malformations might be associated with complete atrioventricular septal defect (CAVSD) such as abnormalities of the left atrioventricular valve. Down syndrome is known to affect the natural history of complete atrioventricular septal defect but associations between Down syndrome and outcomes remain to be established. The purpose of this study was to investigate the impact of Down syndrome on atrioventricular valve morphology and haemodynamics as well as on outcomes in children with CAVSD.

Methods: We performed a single-centre, retrospective and descriptive study with a prospective follow-up in the Congenital Heart Disease Unit of cardiology department over a 9-year period. We compared 2 groups of patients with CAVSD: Down syndrome patients (group 1) and non-Down syndrome patients (group 2). Demographic variables, echocardiographic features and outcomes were studied.

Results: 225 were diagnosed with CAVSD, 121 (54%) in group 1 and 104 (46%) in group 2. Atrioventricular valve annulus was hypoplastic in 6 patients (5.8%) of group 2 whereas all patients in group 1 had a normally developed atrioventricular valve annulus (p = 0.024). Papillary muscles were abnormal in 8 patients (6.6%) in group 1 versus 15 patients (14.4%) of group 2 (p = 0.048). Significant preoperative left atrioventricular valve regurgitation was lower in group 1 patients: 11 (9.1%) versus 23 (22.1%) (p = 0.02). Mortality rate was lower in group 1; 14 (11.5%) versus 23 (22.1%) (p = 0.03).

Conclusion. Down syndrome patients have a better atrioventricular valve anatomy, fewer preoperative left atrioventricular valve regurgitation and a lower long-term mortality rate after surgery.

Keywords: Complete Atrioventricular Septal Defect; Down Syndrome; Left Atrioventricular Valve Dysplasia; Left Atrioventricular Valve Regurgitation; Mortality

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Citation: Meryem Haboub., et al. “Complete Atrioventricular Septal Defect: Impact of Down Syndrome on Atrioventricular Valve Morphology and Haemodynamics and Clinical Outcomes”. EC Cardiology 7.6 (2020): 13-20.

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