Review Article
Volume 7 Issue 8 - 2020
Cardiac Biomarkers: A Beneficial Tool in the Diagnosis and Prognostification in Heart Failure- A Focus on Rheumatic Heart Disease
Sujhithra A1, M Chokkalingam2, S Jayanthi3*, Sanjay Andrew Rajaratnam4, D Danis Vijay3, SH Shifa Meharaj3 and R Vidhya3
1Department of Allied Health Sciences, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education, Kelambakkam,Tamilnadu, India
2Department of Cardiology, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, India
3Department of Microbiology, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, India
4Department of Physiology, Chettinad Hospital and Research Institue(CHRI), Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, India
*Corresponding Author: S Jayanthi, Department of Microbiology, Chettinad Hospital and Research Institute (CHRI), Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, India.
Received: May 20, 2020; Published: July 31, 2020




Abstract

Globally, 26 million people are affected by Heart failure (HF). Greater number of morbidity and mortality due to cardiovascular diseases are reported as a growing problem worldwide.

A biomarker provides valuable information beyond the available clinical tools, as it reflects the pathophysiological mechanism involved and helps the clinicians in making decisions on patient management. Assessment of cardiac biomarkers has established its role in the routine evaluation and treatment of HF patients.

In the field of cardiology, biomarkers levels have a significant impact on the patient management, diagnosis, in assessing the degree of heart failure and to predict the developing cardiac dysfunction in Acute and Chronic Rheumatic Heart Disease. Despite the array of current biomarkers, technological advancement in molecular biology, cell biology and biochemistry, there remains a knowledge gap.

Ultimately, it is a combination of biomarkers and other parameters like Cardiac Imaging proves them as one of the most beneficial tool in diagnosis and risk stratification in Heart failure. A given biomarker can be a prognostic marker and should be more specific with improved calibration, discrimination and reclassification.

In this review article, the role of cardiac biomarkers like Galectin 3, Gelsolin, Matrix Metalloproteinase-9 (MMP-9), NT pro BNP (N-Terminal pro Brain Natriuretic Peptide), Procollagen Type I C Peptide (PICP), soluble Suppression of Tumorigenicity (sST2), Tenascin C (Tn C) in different cardiac conditions causing Heart Failure like Rheumatic Carditis, Rheumatic Heart diseases, Coronary Artery Diseases, Adults with Congenital Heart Diseases are enumerated in brief.

Keywords: Cardiac biomarkers; Heart Failure; Rheumatic Heart Disease; PICP; Tenascin C; Soluble ST2; Predictive Marker

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Citation: S Jayanthi., et al. “Cardiac Biomarkers: A Beneficial Tool in the Diagnosis and Prognostification in Heart Failure- A Social Focus on Rheumatic Heart Disease”. EC Cardiology 7.8 (2020): 36-48.

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