Editorial
Volume 7 Issue 12 - 2020
Gut Microbiota and Atrial Fibrillation
Sunil Reddy D*
Head, Department of Cardiology, Russh Superspeciality Hospital, Hyderabad, Telangana, India
*Corresponding Author: Sunil Reddy D, Head, Department of Cardiology, Russh Superspeciality Hospital, Hyderabad, Telangana, India.
Received: November 19, 2020; Published: November 28, 2020




Atrial fibrillation (AF), despite medical and ablative therapies, remains one of the most prevalent and widespread arrhythmias affecting the quality of human life globally [1]. The heterogeneity of the underlying atrial substrate, extent of atrial fibrosis and the discrepancies among inter-individual electrophysiological characteristics contribute to unpredictable responses to drug or ablation therapy [2]. With the establishment of the heart-gut axis concept, accumulating studies suggest that the gut microbiome plays an important role in the pathogenesis of cardiovascular diseases including initiation and progression of AF. Emerging evidence suggests that through immune system and metabolic alterations, gut microbiota disequilibrium could induce obesity, HTN and T2DM, traditional cardiac risk factors that play an essential role during atrial remodeling in the development of AF [3]. Gut microbiota and its products have also been shown to have an important prognostic value in AF patients [4]. Targeted modification of gut microbiota may be a novel adjunct treatment strategy for AF and its concomitant risk factors in near future.

References

  1. Chugh SS., et al. “Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study”. Circulation 129 (2014): 837-847.
  2. Marrouche NF., et al. “Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study”. The Journal of the American Medical Association 5 (2014): 498-506.
  3. Du X., et al. “Is atrial fibrillation a preventable disease?” Journal of the American College of Cardiology 15 (2017): 1968-1982.
  4. Pastori D., et al. “Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet”. Journal of the American Heart Association 6 (2017): e005784.
  5. Zuo K., et al. “Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation”. Gigascience6 (2019): giz058.
  6. Brown JM and Hazen SL. “Microbial modulation of cardiovascular disease”. Nature Reviews Microbiology 3 (2018): 171-181.
  7. WH Tang and SL Hazen. “The gut microbiome and its role in cardiovascular diseases”. Circulation 135 (2017): 1008-1010.
  8. Zuo Kun., et al. “Duration of Persistent Atrial Fibrillation Is Associated with Alterations in Human Gut Microbiota and Metabolic Phenotypes”. M Systems (2019): 4.
  9. Jiang M., et al. “ALA/LA ameliorates glucose toxicity on HK-2 cells by attenuating oxidative stress and apoptosis through the ROS/p38/TGF-beta1 pathway”. Lipids in Health and Disease 1 (2017): 216.
Citation: Sunil Reddy D. “Gut Microbiota and Atrial Fibrillation”. EC Cardiology 7.12 (2020): 55-56.

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