Review Article
Volume 8 Issue 1 - 2021
Cardiogenic Dementia: The Role of Chronic Cerebral Hypoperfusion in Cardiogenic Dementia and Cognitive Impairment in Patients with Cardiovascular Diseases
Nicholas A Kerna1,2*, Kevin D Pruitt3, Kyle Kadivi4, Uzoamaka Nwokorie5, Olufemi Odugbemi6, Oluwatosin A Atolagbe7, Shain Waugh8 and Emmanuella Solomon9
1SMC–Medical Research, Thailand
2First InterHealth Group, Thailand
3Kemet Medical Consultants, USA
4Global Health Group LLC, USA
5University of Washington, USA
6Olabisi Onabanjo University, Nigeria
7Zorvis Inc., USA
8Fettle Path, USA
9Obafemi Awolowo University, Nigeria
*Corresponding Author: Nicholas A Kerna, SMC-Medical Research, Thailand.
Received: November 30, 2020; Published: December 31, 2020




Abstract

The relationship between the brain and heart has been suspected and alluded to for several millennia. More recently, studies have associated low cardiac functioning with a decline in cognitive ability and established a link between vascular risk determinants and dementia. Cognitive function is dependent on several factors, which affect hemodynamic function and cardiac disease progression, contributing to cognitive decline (termed, cardiogenic dementia). Poor perfusion of cerebral tissues (termed, cerebral hypoperfusion) can adversely affect cognitive function, resulting in reduced attention span and memory. A dysfunction in cerebral autoregulation and neurometabolic inadequacy have been implicated in cognitive decline. Recently, specific treatment, namely cardiac resynchronization, is advancing enhancements in cardiac functioning in patients with symptomatic heart failure by improving cardiac hemodynamics and ejection fractions, resulting in improved executive functioning, global cognition, and visuospatial performance. However, at this time, studies on the efficacy of cardiac resynchronization and lessening the effects of cardiogenic dementia are limited.

Keywords: Alzheimer’s Disease; Cerebral hyperperfusion; Cognitive Decline; Dementia; Proteinopathy; Revascularization

References

  1. Dawson WR and Ebbell B. “The Papyrus Ebers; The Greatest Egyptian Medical Document”. The Journal of Egyptian Archaeology (1938).
  2. Gomes Mda M., et al. “Andreas Vesalius as a renaissance innovative neuroanatomist: his 5th centenary of birth”. Arq Neuropsiquiatr2 (2015): 155-158.
  3. Cardiogenic Dementia”. The Lancet8001 (1977): 27-28.
  4. Mccarthy ST., et al. “Cardiogenic Dementia”. The Lancet (1981).
  5. De La Torre J. “Basics of Alzheimer’s disease prevention”. Journal of Alzheimer’s Disease3 (2010): 687-688.
  6. Bergmann C and Sano M. “Cardiac risk factors and potential treatments in Alzheimer’s disease”. Neurological Research6 (2006): 595-604.
  7. De La Torre JC. “Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia”. Cardiovascular Psychiatry and Neurology (2012).
  8. Lane RJM. “Cardiogenic dementia” revisited”. Journal of the Royal Society of Medicine10 (1991): 577-579.
  9. Koide H., et al. “Improvement of cerebral blood flow and cognitive function following pacemaker implantation in patients with bradycardia”. Gerontology5 (1994): 279-285.
  10. Duschek S., et al. “Essential hypotension is accompanied by deficits in attention and working memory”. Behavioral Medicine4 (2005): 149-158.
  11. Qiu C., et al. “Low blood pressure and risk of dementia in the Kungsholmen project: A 6-year follow-up study”. Archives of Neurology2 (2003): 223-228.
  12. Waldstein SR., et al. “Nonlinear relations of blood pressure to cognitive function: The Baltimore longitudinal study of aging”. Hypertension3 (2005): 374-379.
  13. Duschek S and Schandry R. “Reduced brain perfusion and cognitive performance due to constitutional hypotension”. Clinical Autonomic Research2 (2007): 69-76.
  14. Kennelly S and Collins O. “Walking the cognitive “minefield” between high and low blood pressure”. Journal of Alzheimer’s Disease3 (2012): 609-621.
  15. De La Torre JC. “Cerebral hemodynamics and vascular risk factors: Setting the stage for Alzheimer’s disease”. Journal of Alzheimer’s Disease3 (2012): 553-567.
  16. Duron E and Hanon O. “Vascular risk factors, cognitive decline, and dementia”. Vascular Health and Risk Management 2 (2008): 363-381.
  17. Mosconi L., et al. “Hippocampal hypometabolism predicts cognitive decline from normal aging”. Neurobiology of Aging5 (2008): 676-692.
  18. De La Torre JC. “Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer’s pathogenesis”. In: Neurobiology of Aging2 (2000): 331-342.
  19. Bentourkia M., et al. “Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: Effect of aging”. Journal of the Neurological Sciences1-2 (2000): 19-28.
  20. Heo S., et al. “Resting hippocampal blood flow, spatial memory and aging”. Brain Research (2010).
  21. Gebremedhin D., et al. “Production of 20-HETE and its role in autoregulation of cerebral blood flow”. Circulation Research7 (2000): 60-65.
  22. Qiu C., et al. “The age-dependent relation of blood pressure to cognitive function and dementia”. Lancet Neurology8 (2005): 487-499.
  23. White RP., et al. “Effect of inhibition of nitric oxide synthase on dynamic cerebral autoregulation in humans”. Clinical Science6 (2000): 555-560.
  24. Ambrosius WT., et al. “SPRINT Study Research Group. The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)”. Clinical Trials 5 (2014): 532-546.
  25. Basile J. “Hypertension in the elderly: a review of the importance of systolic blood pressure elevation”. Journal of Clinical Hypertension 2 (2002): 108-112.
  26. Feldstein CA. “Association between chronic blood pressure changes and development of Alzheimer’s disease”. Journal of Alzheimer’s Disease3 (2012).
  27. Raabe RD., et al. “One-year Cognitive Outcomes Associated with Carotid Artery Stent Placement”. Journal of Vascular and Interventional Radiology7 (2010): 983-988.
  28. Jefferson AL., et al. “Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease”. Journal of the American Geriatrics Society7 (2007): 1044-1048.
  29. Qiu C., et al. “Heart failure and risk of dementia and Alzheimer disease: A population-based cohort study”. Archives of Internal Medicine9 (2006): 1003-1008.
  30. De la Torre JC and Mussivand T. “Can disturbed brain microcirculation cause Alzheimer’s disease?” Neurological Research3 (1993): 146-153.
  31. Marshall GA., et al. “Alzheimer's Disease Neuroimaging Initiative. Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease”. Alzheimer's and Dementia 3 (2011): 300-308.
  32. Nelson GS., et al. “Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block”. Circulation25 (2000): 3053-3059.
  33. Hoth KF., et al. “Link between change in cognition and left ventricular function following cardiac resynchronization therapy”. Journal of Cardiopulmonary Rehabilitation and Prevention6 (2010): 401-408.
  34. Dixit NK., et al. “Cardiac resynchronization therapy: A pilot study examining cognitive change in patients before and after treatment”. Clinical Cardiology2 (2010): 84-88.
  35. Festa JR., et al. “Association of low ejection fraction with impaired verbal memory in older patients with heart failure”. Archives of Neurology8 (2011): 1021-1026.
  36. Anazodo UC., et al. “Impaired Cerebrovascular Function in Coronary Artery Disease Patients and Recovery Following Cardiac Rehabilitation”. Frontiers in Aging Neuroscience (2016): 224.
Citation: Kerna NA, Pruitt KD, Kadivi K, Nwokorie U, Odugbemi O, Atolagbe OA, Waugh S, Solomon E. “Cardiogenic Dementia: The Role of Chronic Cerebral Hypoperfusion in Cardiogenic Dementia and Cognitive Impairment in Patients with Cardiovascular Diseases”. EC Cardiology 8.1 (2021): 47-53.

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