Research Article
Volume 8 Issue 3 - 2021
The Rh Factor in Humans: Beyond Blood Compatibility; Examining Associations with Helicobacter pylori, Norovirus, Cholera, Malaria, Cardiovascular Disease, and COVID-19
Nicholas A Kerna1,2*, Uzoamaka Nwokorie3, Abdullah Hafid4, Kevin D Pruitt5, Oluwatosin A Atolagbe6, Fernand Jean-Baptiste7, Shain Waugh8 Joseph Anderson II9 and ND Victor Carsrud10
1SMC–Medical Research, Thailand
2First InterHealth Group, Thailand
3University of Washington, USA
4Academy of Integrative Health and Medicine (AIHM), USA
5Kemet Medical Consultants, USA
6Zorvis Inc., USA
7Department of Biological Sciences, Florida Atlantic University, USA
8Fettle Path, USA
9International Institute of Original Medicine, USA
10Lakeline Wellness Center, USA
*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: February 22, 2021; Published: February 27, 2021




Abstract

The term “Rhesus factor” was put forth by Karl Landsteiner and Alexander S. Wiener in 1937. The serum of rabbits and guinea pigs agglutinated 85% of the human samples following the immunization with RBCs of Macacus rhesus monkeys. If the Rhesus factor is present in blood cells, the blood is termed Rh-positive. In the absence of Rhesus factor, the blood is termed Rh-negative. Rh grouping is significant in assessing blood compatibility, performing a crucial role in Rh-negative women exposed to Rh-positive blood through transfusion or pregnancy. The Rh-negative blood type is distinctly human, originating from a mutation in the RHD gene. Depending on the source, about 85% of the United States’ population is Rh-positive, while 15% is Rh-negative. However, this ratio varies from country to country; globally, the ratio is estimated at 92% Rh-positive with the remaining Rh-negative. Technological advances have resulted in a better understanding of Rh antigens’ molecular basis; approximately 170 alleles of the Rh gene RHD have been identified. It is projected that the percentage of Rh-negative people should drop as the population growth rate in Europe is low, and Europeans contribute significantly to the Rh-negative population. The most familiar and established connection regarding Rh is in blood compatibility. Nevertheless, investigations are ongoing into similarities between ABO grouping and the Rh factor regarding susceptibility or predilection towards specific psychological disorders, physical conditions and diseases, and infections. One aim of future research is in developing a universal blood type, making donor blood more readily available and blood transfusions and immixing harmless.

Keywords: Allele; Antigen; Gene Mutation; COVID-19; Polymorphism; Rhesus Box; Schizophrenia

References

  1. Landsteiner K and Wiener AS. “Studies on an agglutinogen (rh) in human blood reacting with anti-rhesus sera and with human isoantibodies”. Journal of Experimental Medicine 4 (1941): 309-320. https://pubmed.ncbi.nlm.nih.gov/19871137/
  2. Levine P., et al. “The role of isoimmunization in the pathogenesis of erythroblastosis fetalis”. American Journal of Obstetrics and Gynecology 42 (1941): 925-937. https://www.sciencedirect.com/science/article/abs/pii/S0002937841902600
  3. Mollison PL., et al. “Suppression of primary RH immunization by passively-administered antibody. Experiments in volunteers”. Vox Sanguinis 16 (1969): 421-439. https://pubmed.ncbi.nlm.nih.gov/4979251/
  4. Westhoff CM. “The structure and function of the Rh antigen complex”. Seminars in Hematology 1 (2007): 42-50. https://pubmed.ncbi.nlm.nih.gov/17198846/
  5. Freda V., et al. “Rh factor: Prevention of isoimmunization and clinical trials in mothers”. In Science 151 (1966): 828-830. https://pubmed.ncbi.nlm.nih.gov/17746731/
  6. Flegel WA., et al. “Rh phenotype prediction by DNA typing and its application to practice”. In Transfusion Medicine 8 (1998): 281-302. https://www.uni-ulm.de/fileadmin/website_uni_ulm/archiv/wflegel/RH/TME/trans173.pdf
  7. Flegel WA. “The genetics of the Rhesus blood group system”. Blood Transfus 2 (2007): 50-57. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535884/
  8. Shao CP., et al. “Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese”. Vox Sanguinis 83 (2002): 156-161. https://www.researchgate.net/publication/11186409_Molecular_background_of_Rh_D-positive_D-negative_Del_and_weak_D_phenotypes_in_Chinese
  9. Propping P. “Genetische Diagnostik vor dem Hintergrund von Millionen Polymorphismen”. Deutsches Ärzteblatt 101 (2004): 3100-3101. https://www.aerzteblatt.de/archiv/44242/Genetische-Diagnostik-vor-dem-Hintergrund-von-Millionen-Polymorphismen
  10. Wagner FF., et al. “Frequencies of the blood groups ABO, Rhesus, D category VI, Kell, and of clinically relevant high-frequency antigens in South Western Germany”. Infusionstherapie und Transfusionsmedizin 22 (1995): 285-290. https://www.karger.com/Article/Abstract/223144
  11. Wagner FF and Flegel WA. “RHCE represents the ancestral RH position, while RHD is the duplicated gene”. Blood 99 (2002): 2272-2273. https://pubmed.ncbi.nlm.nih.gov/11902138/
  12. Wagner FF., et al. “Three molecular structures cause Rhesus D category VI phenotypes with distinct immunohematologic features”. Blood21 (1998): 517-568. https://pubmed.ncbi.nlm.nih.gov/9490704/
  13. Lippert H-D and Flegel WA. “Kommentar zum Transfusionsgesetz (TFG) und den Hämotherapie Richtlinien”. Heidelberg: Springer (2002). https://www.springer.com/de/book/9783662081372
  14. Wagner FF., et al. “Weak D alleles express distinct phenotypes”. Blood 95 (2000): 2699-2708. https://pubmed.ncbi.nlm.nih.gov/10753853/
  15. Garratty G. “Do we need to be more concerned about weak D antigens?” Transfusion 45 (2005): 1547-1551. https://pubmed.ncbi.nlm.nih.gov/16181202/
  16. Wagner FF., et al. “Molecular basis of weak D phenotypes”. Blood 93 (1999): 385-393. https://pubmed.ncbi.nlm.nih.gov/9864185/
  17. Lo YMD., et al. “Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma”. The New England Journal of Medicine 339 (1998): 1734-1738. https://pubmed.ncbi.nlm.nih.gov/9845707/
  18. Flegel WA., et al. “Rh phenotype prediction by DNA typing and its application to practice”. Transfusion Medicine 8 (1998): 281-302. https://www.uni-ulm.de/fileadmin/website_uni_ulm/archiv/wflegel/RH/TME/trans173.pdf
  19. Wagner FF and Flegel WA. “RHD gene deletion occurred in the Rhesus box”. Blood 95 (2000): 3662-3668. https://pubmed.ncbi.nlm.nih.gov/10845894/
  20. Flegel WA. “Homing in on D antigen immunogenicity”. Transfusion 45 (2005): 466-468. https://pubmed.ncbi.nlm.nih.gov/15819664/
  21. Yasuda H., et al. “Secondary anti-D immunization by DEL red blood cells”. Transfusion 45 (2005): 1581-1584. https://onlinelibrary.wiley.com/doi/10.1111/j.1537-2995.2005.00579.x
  22. Wagner T., et al. “Anti-D immunization by DEL red blood cells”. Transfusion 45 (2005): 520-526. https://pubmed.ncbi.nlm.nih.gov/15819672/
  23. Marini AM., et al. “The human Rhesus associated RhAG protein and a kidney homologue promote ammonium transport in yeast”. Nature Genetics 26 (2000): 341-344. https://www.nature.com/articles/ng1100_341
  24. Gilmiyarova FN., et al. Kliniceskaja Laboratornaja Diagnostika 4 (2020): 216-221.
  25. Ewald DR and Sumner SC. “Blood type biochemistry and human disease”. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 6 (2016): 517-535. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061611/
  26. Anstee DJ. “The relationship between blood groups and disease”. Blood 23 (2010): 4635-4643. https://ashpublications.org/blood/article/115/23/4635/27755/The-relationship-between-blood-groups-and-disease
  27. Liu N., et al. “The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis”. Blood Reviews (2020): 100785. https://pubmed.ncbi.nlm.nih.gov/33309392/
  28. Pourali F., et al. “Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis”. New Microbes and New Infections 37 (2020): 100743. https://pubmed.ncbi.nlm.nih.gov/32837730/
  29. Taha SAH., et al. “Individuals with a Rh-positive but not Rh-negative blood group are more vulnerable to SARS-CoV-2 infection: demographics and trend study on COVID-19 cases in Sudan”. New Microbes and New Infections 38 (2020): 100763. https://pubmed.ncbi.nlm.nih.gov/32983543/
  30. Sarwar A and Citla Sridhar D. “Rh-Hemolytic Disease”. In: StatPearls. Treasure Island (FL): StatPearls Publishing (2020). https://www.ncbi.nlm.nih.gov/books/NBK560488/
  31. Costumbrado J., et al. “Rh Incompatibility”. In: StatPearls. Treasure Island (FL): StatPearls Publishing (2020). https://www.ncbi.nlm.nih.gov/books/NBK459353/
Citation: Kerna NA, Nwokorie U, Hafid A, Pruitt KD, Atolagbe OA, Jean-Baptiste F, Waugh S, Anderson II J. Carsrud NDV. “The Rh Factor in Humans: Beyond Blood Compatibility; Examining Associations with Helicobacter pylori, Norovirus, Cholera, Malaria, Cardiovascular Disease, and COVID-19”. EC Gynaecology 8.3 (2021): 57-65.

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