Research Article
Volume 7 Issue 1 - 2020
Comparison between PCI in Anterior ST-Elevation Myocardial Infarction and Equivalents in Gaza (PCI-STEMI)
Mohammed Habib*
Cardiology Department, Alshifa Hospital, Gaza, Palestine
*Corresponding Author: Mohammed Habib, Cardiology Department, Alshifa Hospital, Gaza, Palestine.
Received: December 05, 2019; Published: December 12, 2019




Abstract

Background: A primary percutaneous coronary (PCI) intervention and pharmaco-invasive (PCI) continues to be the optimal reperfusion therapy in patients with anterior ST elevation myocardial infarction (STEMI) however, the optimal treatment in patients with anterior STEMI equivalents (wellness and De Winter syndromes) is unknown.

Methods: Patients presenting within 2 hours of symptom onset, divided according to electrocardiography (ECG) into two groups, the first group: acute anterior STEMI treated by primary PCI < 2 hours or pharmaco-invasive PCI 2 - 24 hours after streptokinase, and second group: acute anterior STEMI equivalents (wellness and De Winter syndromes) treated with early PCI < 24 hours. The primary (efficacy) endpoint a composite of death, shock and congestive heart failure at 30 days after hospitalization.

Results: Total 173 patients (134 patients: anterior STEMI, 39 patients: Anterior STEMI Equivalents) with mean age 56.2 ± 9.4 years, the mean age was 55.1 ± 9.2 years for the Anterior STEMI group, and 59.7 ± 9.1 years in Anterior STEMI equivalents group. (P:0.007). The female gender was higher in Anterior STEMI Equivalents compared with anterior STEMI (P: 0.036). Efficacy (primary) endpoint: total death, shock or heart failure at 30 days after hospitalization was seen in myocardial infarction was significantly higher in patient with anterior STEMI group compared with anterior STEMI equivalent group (P:0.011). the total death, shock and heart failure were significant in anterior STEMI group (P: 0.047, 0.024 and 0.028) respectively.

Conclusion: A strategy of early PCI less than 24 hours in patients with Anterior STEMI Equivalents has safe and less adverse events than anterior STEMI with primary PCI < 2 hours and/or pharmaco-invasive PCI 2-24 hours after streptokinase administration.

Keywords: Percutaneous Coronary (PCI); ST Elevation Myocardial Infarction (STEMI)

References

  1. O’Gara PT., et al. “2013 ACCF/AHA guideline for the management of ST elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines”. Journal of the American College of Cardiology 61 (2013): e78-e140.
  2. de Zwaan C., et al. “Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction”. American Heart Journal 103.4 (1982): 730-736.
  3. de Winter RJ., et al. “A new ECG sign of proximal LAD occlusion”. New England Journal of Medicine 359 (2008): 2071-2073.
  4. Verouden NJ., et al. “Persistent precordial “hyperacute” T-waves signify proximal left anterior descending artery occlusion”. Heart 95 (2009): 1701-1706.
  5. Shams M., et al. “Optimizing electrocardiogram interpretation and catheterization laboratory”. Clinical Practice and Cases in Emergency Medicine 178.3 (2017). 
  6. Reddy K., et al. “Recent advances in the diagnosis and treatment of acute myocardial infarction”. World Journal of Cardiology 7 (2015): 243.
  7. Yusuf S., et al. “Global burden of cardiovascular diseases: part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies”. Circulation 104 (2001): 2855-2864.
  8. Armstrong PW., et al. “Fibrinolysis or primary PCI in ST- segment elevation myocardial infarction”. New England Journal of Medicine 368 (2013): 1379-1387.
  9. RJ de Winter., et al. “A new ECG sign of proximal LAD occlusion”. New England Journal of Medicine 359.19 (2008): 2071-2073.
  10. IC Rokos., et al. “Appropriate cardiac cathlab activation: optimizing electrocardiogram interpretation and clinical decision-making for acute ST-elevation myocardial infarction”. American Heart Journal 160.6 (2010): 995-1003.
  11. de Zwaan C., et al. “Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction”. American Heart Journal 103.4 (1982): 730-736.
  12. Rhinehardt J., et al. “Electrocardiographic manifestations of Wellens' syndrome”. American Journal of Emergency Medicine 20.7 (2002): 638-643.
  13. B Ibanez., et al. “2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation”. European Heart Journal 39 (2017): 119-177.
  14. PT O’Gara., et al. “ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association taskforce on practice guidelines”. Circulation 127.4 (2013): e362-e425.
Citation: Mohammed Habib., et al. “Comparison between PCI in Anterior ST-Elevation Myocardial Infarction and Equivalents in Gaza (PCI-STEMI)”. EC Cardiology 7.1 (2020): 01-08.

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