Case Report
Volume 20 Issue 5 - 2021
Minimally Invasive “IPG-Det Technique” with Autologous CGF and Human Umbilical Cord Blood Derived Mesenchymal Stem Cells towards Posterior Atrophic Maxilla Reconstruction - Case Report
Ioannis P Georgakopoulos1,2, Vasileios Ntontoulos1,2*, Panagiotis G Georgakopoulos1,2, Aggelos-Taxiarchis Georgakopoulos2, Stavros Tsantis3, Edit Xhanjanka4, Athanasios Kossyvakis5, Dora Dailiana2, Gianna Dipalma1,2 and Francesco Inchingolo1,2
1Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy
2World Academy of Growth Factors and Stem Cells in Dentistry, Greece
3Department of Medical Physics, School of Medicine, University of Patras, Rion, Greece
4Department of Prosthodontics, Faculty of Dental Medicine, University of Medicine, Tirana, Albania
5Hellenic Pasteur Institute, Athens, Greece
*Corresponding Author: Vasileios Ntontoulos, Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy and World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece.
Received: March 07, 2021; Published: April 21, 2021




Abstract

Rehabilitation of maxilla in Implant Dentistry, especially in posterior edentulism is primarily treated with large and painful surgical approaches due to residual ridge atrophy and maxillary sinus pneumatization. Sinus Floor Elevation (SFE), especially in its “lateral version” is considered as the “gold-standard” for over four decades, despite the well documented post-operative morbidity and complications. As an alternative, the novel protocol named “IPG-DET Technique” minimally invasive and equally safe-efficient, promotes sinus membrane intentional perforation secured by healing and augmentative potential of autologous concentrated growth factors and CD34-Stem Cells Matrix.

This study further investigates the efficiency and healing process of “IPG-DET Technique” amplified by Mesenchymal Stem Cells clinical use, derived from human Umbilical Cord Blood for posterior atrophic maxilla reconstruction. Preliminary results have shown safe and inductive bone regeneration within sinus cavity. All implants loaded, 4 months after implant placement, showed high primary stability until final fixed prosthetic rehabilitation.

Keywords: Human Umbilical Cord Blood Stem Cells; Bone Augmentation; IPG-DET Technique; Sinus Membrane Intentional Perforation; CD34 -Stem Cells

References

    1. Eun Seok Jang., et al. “A Case of Maxillary Sinusitis after Sinus Floor Augmentation”. Korean Journal of Otorhinolaryngology-Head and Neck Surgery 53 (2010): 310-312.
    2. Fugazzotto P., et al. “Complications When Augmenting the Posterior Maxilla”. Dental Clinics of North America 59 (2015): 101-126.
    3. Rodella LF., et al. “Growth Factors, CD34 Positive Cells, and Fibrin Network Analysis in Concentrated Growth Factors Fraction”. Microscopy Research and Technique8 (2011): 772-777.
    4. Inchingolo F., et al. “Computer-based quantification of an atraumatic sinus augmentation technique using CBCT”. Journal of Biological Regulators and Homeostatic Agents 6-2 (2019): 31-39.
    5. Georgakopoulos I., et al. “A Case-Study of Seven Dental Implants Placed in the Maxillary Sinus with Intentional Schneiderian Membrane Perforation”. The Journal of Implant and Advanced Clinical Dentistry1 (2014): 9-19.
    6. Georgakopoulos PI., et al. “IPG-DET Minimal Invasive Sinus Implant Placement and Grafting without Sinus Floor Elevation – The Evolution of New Age Concepts”. Dentistry 6 (2016): 375.
    7. Ntontoulos V., et al. “Innovative “IPG-DET Technique” Combined with Autologous CGF with Stem Cells CD34+ for the Rehabilitation of the Posterior Atrophic Maxilla”. EC Dental Science9 (2020): 119-126.
    8. McGuckin C., et al. “Culture of embryonic-like stem cells from human umbilical cord blood and onward differentiation to neural cells in vitro”. Nature Protocols 3 (2008): 1046-1055.
    9. Marino L., et al. “Mesenchymal Stem Cells from the Wharton’s Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential”. International Journal of Stem Cells2 (2019): 218-226.
    10. Thomson JA., et al. “Embryonic stem cell lines derived from human blastocysts”. Science 282 (1998): 1145-1147.
Citation: Ioannis P Georgakopoulos., et al. “Minimally Invasive “IPG-Det Technique” with Autologous CGF and Human Umbilical Cord Blood Derived Mesenchymal Stem Cells towards Posterior Atrophic Maxilla Reconstruction - Case Report”. EC Dental Science 20.5 (2021): 43-50.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 21, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk