Case Report
Volume 20 Issue 5 - 2021
Minimally Invasive “IPG-Det Technique” with Autologous CGF and Human Umbilical Cord Blood Derived Mesenchymal Stem Cells towards Posterior Atrophic Maxilla Reconstruction - Case Report
Ioannis P Georgakopoulos1,2, Vasileios Ntontoulos1,2*, Panagiotis G Georgakopoulos1,2, Aggelos-Taxiarchis Georgakopoulos2, Stavros Tsantis3, Edit Xhanjanka4, Athanasios Kossyvakis5, Dora Dailiana2, Gianna Dipalma1,2 and Francesco Inchingolo1,2
1Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy
2World Academy of Growth Factors and Stem Cells in Dentistry, Greece
3Department of Medical Physics, School of Medicine, University of Patras, Rion, Greece
4Department of Prosthodontics, Faculty of Dental Medicine, University of Medicine, Tirana, Albania
5Hellenic Pasteur Institute, Athens, Greece
*Corresponding Author: Vasileios Ntontoulos, Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy and World Academy of Growth Factors and Stem Cells in Dentistry, Athens, Greece.
Received: March 07, 2021; Published: April 21, 2021


Rehabilitation of maxilla in Implant Dentistry, especially in posterior edentulism is primarily treated with large and painful surgical approaches due to residual ridge atrophy and maxillary sinus pneumatization. Sinus Floor Elevation (SFE), especially in its “lateral version” is considered as the “gold-standard” for over four decades, despite the well documented post-operative morbidity and complications. As an alternative, the novel protocol named “IPG-DET Technique” minimally invasive and equally safe-efficient, promotes sinus membrane intentional perforation secured by healing and augmentative potential of autologous concentrated growth factors and CD34-Stem Cells Matrix.

This study further investigates the efficiency and healing process of “IPG-DET Technique” amplified by Mesenchymal Stem Cells clinical use, derived from human Umbilical Cord Blood for posterior atrophic maxilla reconstruction. Preliminary results have shown safe and inductive bone regeneration within sinus cavity. All implants loaded, 4 months after implant placement, showed high primary stability until final fixed prosthetic rehabilitation.

Keywords: Human Umbilical Cord Blood Stem Cells; Bone Augmentation; IPG-DET Technique; Sinus Membrane Intentional Perforation; CD34 -Stem Cells


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Citation: Ioannis P Georgakopoulos., et al. “Minimally Invasive “IPG-Det Technique” with Autologous CGF and Human Umbilical Cord Blood Derived Mesenchymal Stem Cells towards Posterior Atrophic Maxilla Reconstruction - Case Report”. EC Dental Science 20.5 (2021): 43-50.

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