Research Article
Volume 20 Issue 5 - 2021
An In Vitro Assessment of the Antifungal Efficacy of Two Commercially Available Soft Denture Liners Modified with Silver Zinc Zeolite Nanoparticles
Amanda Nadia Ferreira1*, Kathleen D’Souza1, Meena Aras2, Vidya Chitre3, Shobha Parsekar4 and Maria Jose Pinto5
1Lecturer at the Department of Prosthodontics and Crown and Bridge at Goa Dental College and Hospital, Bambolim, Goa
2Head of Department of Prosthodontics and Crown and Bridge at Goa Dental College and Hospital, Bambolim, Goa
3Assistant Professor at the Department of Prosthodontics and Crown and Bridge at Goa Dental College and Hospital, Bambolim, Goa
4Professor at the Department of Microbiology at Goa Medical College and Hospital, Bambolim, Goa
5Associate Professor at the Department of Microbiology at Goa Medical College and Hospital, Bambolim, Goa
*Corresponding Author: Amanda Nadia Ferreira, Lecturer at the Department of Prosthodontics and Crown and Bridge at Goa Dental College and Hospital, Bambolim, Goa.
Received: February 11, 2021; Published: April 27, 2021




Abstract

Statement of the Problem: The treatment of oral candidiasis, involves adjusting the old prosthesis, use of temporary soft denture liners and initiation of anti-fungal therapy. However, due to lack of patient’s compliance, copious amount of saliva and increased evidence of drug resistance, there is a need for an improved drug and drug delivery system.

Aims: Assess the antifungal efficacy of two different brands of modified denture liners (Visco gel-Dentsply and Soft denture liner-GC) containing silver zinc zeolite towards Candida albicans.

Methods and Material: The mean inhibition diameter (MID) was used to test the antifungal efficacy of 2% SZZ and 5% fluconazole in two commercially available soft denture liners: Visco gel and GC. MIDs were measured at day 1, day 3, day 7 and day 15, while carrying out the monitoring daily. Data was statistically analysed using one way ANOVA and post hoc Bonferroni test.

Results: 2% w/w SSZ in GC soft denture liner was found to be the most effective (p < 0.001).

Conclusion: Within the limitations of the study, it can be concluded that SZZ and fluconazole mixed with denture liners can be used against C. albicans. 5% fluconazole is the recommended choice for short term antifungal efficacy, while 2% SZZ is recommended when prolonged antifungal efficacy is indicated. GC soft denture liner was the recommended choice in both these cases.

 

Keywords: Silver Zinc Zeolite Nanoparticles; Soft Denture Liner; Candida albicans; Antifungal Efficacy

References

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Citation: Amanda Nadia Ferreira., et al. “An In Vitro Assessment of the Antifungal Efficacy of Two Commercially Available Soft Denture Liners Modified with Silver Zinc Zeolite Nanoparticles”. EC Dental Science 20.5 (2021): 95-104.

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