Abstract

Introduction: Platelet concentrates are autogenous regenerative preparations, obtained through the centrifugation of a blood sample from the patient [1]. In 1998, the initial production of platelet-rich plasma (PRP) was presented and in 2000 the second platelet rich fibrin (PRF) was introduced as well. The Concentrated Growth Factor (CGF) is a novel second generation platelet concentrate which was developed by Sacco in 2006 and was obtained from blood samples through a simple and standardized separation protocol by means of a specific centrifuge [2].

CGF is fibrin rich organic matrix which can stimulate cell proliferation, regeneration, chemotaxis and angiogenesis and contains growth factors in the platelets such as [3]:

1. Platelet-derived growth factor (PDGF)
2. Transforming growth factors (TGF-β1)
3. Epidermal growth factor (EGF)
4. Fibroblast growth factor (FGF)
5. Insulin growth factor-I (IFG-I)
6. Vascular endothelial growth factors (VEGF)
7. Leukocytes and CD34+ stem cells.

Case Report: This article presents the “IPG-DET” Technique, an innovative technique by which the rapid placement of implants in the sinus cavity by means of intentional perforation of the sinus membrane (following a certain clinical protocol). In other words, the sinus floor elevation procedure is not necessary anymore provided the clinician follows the surgical protocol of this innovative technique. The “IPG-DET”, involves the simultaneous placement of concentrated growth factors CGF and stem-cells-CD34+ as well as bone grafting within the osteotomy site and through immediate implant placement the sinus adjusts to the new state of affairs without any complications [4].

Conclusion: “IPG-DET” technique proves that minimal invasive implant placement without applying sinus floor elevation has plenty benefits with minimum complications [4].

Keywords: Concentrated Growth Factors (CGF); Immediate Implant Placement; Cone Beam Computed Tomography (CBCT); Liquid Phase Concentrate Growth Factors (LPCGF)

References

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3. Chen J and Jiang H. “A Comprehensive Review of Concentrated Growth Factors and Their Novel Applications in Facial Reconstructive and Regenerative Medicine”. Aesthetic Plastic Surgery 44 (2020): 1047-1057.
4. Ioannis Georgakopoulos., et al. “A Case-Study of Seven Dental Implants Placed in the Maxillary Sinus with Intentional Schneiderian Membrane Perforation”. The Journal of Implant and Advanced Clinical Dentistry1 (2014): 9-19.
5. Sureshbabu NM., “Concentrated Growth Factor - Surgical Management of Large Periapical Lesion Using a Novel Platelet Concentrate in Combination with Bone Graft”. Annals of Maxillofacial Surgery 1 (2020): 246-250.
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