Abstract

Background: Periodontal regenerative therapy is rapidly evolving, with a major shift from bio compatible material to human derived biomaterials. Demineralized Freeze Dried Bone Allograft (DFDBA), has both osteoinductive and osteoconductive property, hence is utilized in periodontal bone defects. To enhance the regenerative outcomes, various additives viz commercial growth factors, PRP, PRF etc. are adjunctively used along with bone grafts. Titanium-prepared, Platelet Rich Fibrin (T-PRF) is one such new concentrate used in regenerative surgery.

Aim of the Study: The aim of the present trial was to evaluate clinically and radiographically the efficacy of autologous L-PRF (Leukocyte Platelet Rich Fibrin) and T-PRF as an adjunct to DFDBA in the treatment of intrabony defects in chronic periodontitis patients.

Materials and Methods: 30 intrabony sites were randomly assigned into two treatment groups as group I (Control): DFDBA + L-PRF and group II (Test): DFDBA + T-PRF. Venous blood samples were collected and PRF obtained after centrifugation was used in combination with bone graft (DFDBA) in intra bony defects. Clinical parameters PPD and RAL and radiographic defect depth of randomly selected sites in group I and group II were recorded at baseline, 3^rd, 6^th and 9^th months after therapy.

Results: Within each group, significant improvements (P < 0.05) were found for all variables in 9-month follow-up compared with baseline. Greatest reduction in the PPD of 60.66% and RAL gain of 1.6 mm was found in group II and radiographic bone gain of 3.07 mm (21.64%) at the end of 9^th month in group II. Percentage changes of radiographic defect depth in both the groups were found to be significant from baseline to 9^th month, greatest reduction of 3.07 (21.64%) was found in group II at 9^th month interval whereas in group I it was 2.14 (14.53%).

Conclusion: Significant improvements in clinical and radiographic parameters indicate success of regenerative therapy using T- PRF over L-PRF with DFDBA.

Keywords: Chronic Periodontitis; Periodontal Regeneration; Intrabony Defects; Platelet Rich Fibrin; Titanium - Platelet Rich Fibrin; Allograft; DFDBA

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