Review Article
Volume 20 Issue 6 - 2021
PRF: A Boon in Periodontal Therapy
Banashree Baishya Swain1*, Naina Pattnaik2 and Saumyashree Mahapatra3
1Senior Lecturer, Department of Periodontics, Hi-Tech Dental College and Hospital, Pandara Bhubaneswar, Odisha, India
2Reader, Department of Periodontics, Hi-Tech Dental College and Hospital, Pandara Bhubaneswar, Odisha, India
3Intern, Hi-Tech Dental College and Hospital, Pandara Bhubaneswar, Odisha, India
*Corresponding Author: Banashree Baishya Swain, Senior Lecturer, Department of Periodontics, Hi-Tech Dental College and Hospital, Pandara Bhubaneswar, Odisha, India.
Received: April 12, 2021s; Published: May 25, 2021




Abstract

Platelet concentrates, mostly platelet-rich fibrin, has gained path breaking significance in various medical and dental fields, because of their potential to stimulate and improve regeneration of hard and soft tissues. This platelet concentrate is prepared from the patient’s blood and shows promising result in various surgical fields including oral and maxillofacial surgery. The effects of these biomaterials are described to be a result of the large concentration of platelets which contain a wide range of growth factors. The aim of this article is to introduce the principle and function of these platelet concentrates, to review their preparation, use in different fields.

Keywords: Platelet-Rich Plasma; Platelet-Rich Fibrin; Platelets; PRP; PRF

References

  1. Zan der HA., et al. “Goals of periodontal therapy”. Journal of Periodontology 47 (1976): 261-266.
  2. Preeja C and Arun S. “Platelet Rich fibrin: its role in periodontal regeneration”. The Saudi Journal for Dental Research 5 (2014): 117-122.
  3. Dohan Ehrenfest DM., et al. “Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L- PRF)”. Trends in Biotechnology 27 (2009): 158-167.
  4. Dohan DM., et al. “Platelet rich fibrin (PRF):a second generation platelet concentrate .Part-1: technological concepts and evolution”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 101 (2006): e37-44.
  5. Kingsley CS. “Blood coagulation; evidence of an antagonist to factor VI in platelet rich human plasma”. Nature 173 (1954): 723-724.
  6. Knighton DR., et al. “Classification and treatment of chronic non healing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF)”. Annals of Surgery 204 (1986): 322-330.
  7. Choukroun J., et al. “Une opportunité en paro-implantologie: le PRF”. Implantodontie 42 (2001): 5562.
  8. Bielecki TM., et al. “Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study”. The Bone and Joint Journal 89 (2007): 417-420.
  9. Tunalı M., et al. “In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate”. British Journal of Oral and Maxillofacial Surgery 51 (2013): 438-443.
  10. Ghanaati S., et al. “Advanced Platelet-Rich Fibrin: A New Concept for Cell-Based Tissue Engineering by Means of Inflammatory Cells”. The Journal of Oral Implantology 40 (2014): 679-689.
  11. Miron RJ., et al. “Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?” Clinical Oral Investigations 21 (2017): 2619-2627.
  12. Kobayashi E., et al. “Comparative release of growth factors from PRP, PRF, and advanced-PRF”. Clinical Oral Investigations 20 (2016): 2353-2360.
  13. Dohan DM., et al. “Platelet rich fibrin: a second generation platelet concentrate. Part2: Platelet related biological features”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 101 (2006): e45-e50.
  14. Dohan DM., et al. “Three dimensional architecture and cell composition of a Choukroun’s Platelet rich fibrin clot and membrane”. Journal of Periodontology 81 (2010): 546-555.
  15. Aroca S., et al. “Clinical evolution of a modified coronally advanced flap alone or in combination with a platelet rich fibrin membrane for treatment of adjacent multiple gingival recession: A 6 month study”. Journal of Periodontology 80 (2009): 244-252.
  16. Choukroun J., et al. “PRF: a 2nd generation platelet concentrate. Clinical effects on tissue healing”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 101 (2006): e56-e60.
  17. Girish Rao., et al. “Bone regeneration with PRF Gel”. Journal of Oral and Maxillofacial Surgery 12 (2013): 11-16.
  18. Hagolin DR and Lines GK. “Prevention of localized osteitis in mandibular 3rd molar sites using PRF”. International Journal of Dentistry (2013): 875380.
  19. Sharma A and Pradeep AR. “Autologous platelet rich fibrin in the treatment of mandibular degree2 furcation defects: a randomized control trials”. Journal of Periodontology l82 (2011): 1396-1403.
  20. Pradeep AR., et al. “Platelet rich fibrin combined with a porous Hydroxyapatite graft for the treatment of 3 wall infra bony defects in chronic periodontitis: a randomized controlled clinical trial”. Journal of Periodontology 88 (2017): 1288-1296.
  21. Rajaram V., et al. “Platelet rich fibrin in double lateral sliding bridge flap procedure for gingival recession coverage: an original study”. Journal of Indian Society of Periodontology 19 (2015): 665-670.
  22. Tajima N., et al. “Evaluation of sinus floor augmentation with simultaneous implant placement using PRF as sole graft material”. The International Journal of Oral and Maxillofacial Implants 28 (2013): 77-83.
  23. Miron RJ., et al. “Use of platelet-rich fibrin in regenerative dentistry: a systematic review”. Clinical Oral Investigations 21 (2017): 1913-1927.
  24. Varela HA., et al. “Injectable platelet rich fibrin: cell content, morphological, and protein characterization”. Clinical Oral Investigations 23 (2019): 1309-1318.
  25. Uzun BC., et al. “Effectiveness and predictability of titanium-prepared platelet-rich fibrin for the management of multiple gingival recessions”. Clinical Oral Investigations 22 (2018): 1345-1354.
  26. Masuki H., et al. “Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF)”. International Journal of Implant Dentistry 2 (2016): 19.
Citation: Banashree Baishya Swain., et al. “PRF: A Boon in Periodontal Therapy”. EC Dental Science 20.6 (2021): 15-20.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


October Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the October issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before November 01, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk