Research Article
Volume 20 Issue 7 - 2021
Comparison of Bone Regeneration of Mandibular Bone Defects Using Natix and Bio_oss with Autogenous Bone in Dogs
Janet Moradihaghgoo1, Masoumeh Khoshhal1, Bita Maleki2, Mohammad Hosseinipanah3, Ghasem Solgi4, Abbas Moghimbeigi5, Nazli Rabienejad1* and Fatemeh Cheraghi6
1Assistant Professor, Periodontology Department, Dentistry Faculty, Hamadan Medical Sciences University, Hamadan, Iran
2Periodontist, Iran
3Assistant Professor, Department of Anatomy, Hamedan University of Medical Sciences, Hamadan, Iran
4Associate Professor of Immunology, Hamedan University of Medical Sciences, Hamadan, Iran
5Professor of Biostatistics, Hamedan University of Medical Sciences, Hamadan, Iran
6Dentistry Faculty, Hamadan Medical Sciences University, Hamadan, Iran
*Corresponding Author: Nazli Rabienejad, Assistant Professor, Periodontology Department, Dentistry Faculty, Hamadan Medical Sciences University, Hamadan, Iran.
Received: May 31, 2021; Published: June 29, 2021


Statement of the Problem: Discovery of bone substitute that enhance bone formation or improve bone healing is needed for the treatment of bone trauma and surgery. The use of autogenous bone grafts requires a harvesting procedure at a donor site, which means increased morbidity. In addition, graft resorption is a problem. One way to overcome this problem would be to use bone substitutes as a osteoconductive scaffold for bone regeneration from the residual bone.

Purpose: The aim of this study is to evaluate the effect of bovine inorganic bone (Bio-Oss) and Natix (Tigran PTG) and Autogenous Bone on bone regeneration.

Materials and Methods: In this interventional in-vivo study, bone cavities with 3 × 5 mm in diameter were prepared in both sides of the mandible of 4 male adult Terrier dogs. The cavities were divided into 4 groups according to the filling material as follows: Bio-oss, Natix, autogen and control. The animals were sacrificed after 14 days and histological and histomorphometrical analysis was performed.

Results: There was no significant differences between groups in inflammatory response,bone vitality and new bone type with use of Kruskal-wallis analysis. There was statistical difference, in bone formation between autogenous group and others.

Conclusion: According to this study, There was no significant differences between control group and biomaterial groups(Bio-oss and Natix) in amount of bone formation. It means that use of bone materials can’t be effective in non-pathologic and non-critical defects.


Keywords: Bone Regeneration; Bio-oss; Natix; Animal Study


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Citation: Nazli Rabienejad., et al. “Comparison of Bone Regeneration of Mandibular Bone Defects Using Natix and Bio_oss with Autogenous Bone in Dogs”. EC Dental Science 20.7 (2021): 78-88.

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