Volume 20 Issue 7 - 2021
Oral Squamous Cell Carcinoma Tumour Microenvironment as the Ideal Niche for Keystone Periodontal Pathogens
Manosha Perera1* and Irosha Perera2
1School of Dentistry and Oral Health, Griffith University (Alumnus), Queensland, Australia
2Preventive Oral Health Unit, The National Dental Hospital (Teaching), Colombo, Sri Lanka
*Corresponding Author: Manosha Perera, School of Dentistry and Oral Health, Griffith University (Alumnus), Queensland, Australia.
Received: June 25, 2021; Published: June 30, 2021

Findings on functional prediction of metagenome demonstrated more consistence than compositional profiles of bacteriome associated with Oral Squamous Cell Carcinomas (OSCC)s [1]. Moreover, speculations on functional capacity of the metagenome of polymicrobial, inflammatory diseases, using hypothetical models based on core community ecological theories, gained much attention in the recent past [2,3]. Evidently, keystone pathogen mediated polymicrobial synergy and dysbiosis (PSD) model developed for periodontitis provides the rationale on successful colonization of periodontal bacteria in the immunosuppressive OSCC tumour microenvironment [2]. This efficacious colonization seems to be more of a consequence of oral carcinogenesis than a cause in most instances with known aetiology. It has been demonstrated that the oral microbiome acts as a co-factor in the initiation and progression of oral cancer with well-known life style related modifiable risk factors [3,4]. However, those initial ‘apprentice’ might convert to ‘expert’ as they can enhance the carcinogenesis with their inflammophilic, carcinogenic, immunogenic and toxic attributes as the time progressed, according to the latest in-vitro an invivo experiments [5]. In light of these stirring findings, it is worthwhile to highlight the intrinsic factors which may facilitate the successful colonization of keystone periodontal pathogens in OSCC tumour microenvironment.


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Citation: Manosha Perera and Irosha Perera. “Oral Squamous Cell Carcinoma Tumour Microenvironment as the Ideal Niche for Keystone Periodontal Pathogens”. EC Dental Science 20.7 (2021): 132-134.

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