Research Article
Volume 21 Issue 7 - 2022
Ultrasound Diagnosis of Major Salivary Gland Tumors
Rizvan Ya Abdullaiev1*, Valeriia Krynychko2, Andri Yefimenko1, Maryna Bondarenko2, Irina Kryzhanovskaya1, Valeriy Lysenko V1 and Sergey Yefimenko1
1Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
2Kharkiv National University Named After V.N. Karazin, Kharkiv, Ukraine
*Corresponding Author: Rizvan Ya Abdullaiev, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine.
Received: June 06, 2022; Published: June 27, 2022




Abstract

Introduction: Defeat of the major salivary glands occupies 3 - 4% of all cases of head and neck cancer. Ultrasonography is the main imaging method for diagnosing pathologies of the major salivary glands. The aim of this study was to evaluate the possibilities of ultrasonography in the diagnosis of tumor formations of the large salivary glands.

Materials and Methods: A retrospective analysis of the results of ultrasonography in 61 patients aged 26 - 73 years operated on for tumors of the major salivary glands was carried out. The quantitative and qualitative echographic parameters were studied. Results reported as mean (standard deviation) and p < 0.05 were considered significant.

Results: Benign tumors of the major salivary glands were diagnosed in 49 (80.3 ± 5.1%) patients (P < 0.001), carcinoma in 12 (19.7 ± 5.1%) patients. Pleomorphic adenoma was diagnosed in 31 (50.8 ± 6.4%) cases, Warthin’s tumour - in 18 (29.5 ± 5.8%) cases, Mucoepidermoid carcinoma - in 5 (8.2 ± 3.5%) cases, Acinic cell carcinoma - in 4 (6.6 ± 3.1%) cases, Myoepithelial carcinoma - in 3 (4.9 ± 2.8%) cases, respectively.

Conclusion: Ultrasonography is an informative and affordable method for detecting salivary gland masses. Pleomorphic adenoma occurred significantly more frequently than Warthin tumors and carcinoma (P < 0,05 and P < 0,001). The main echographic signs of benign tumor of the salivary glands are clear, even contours, homogeneous structure and mild vascularization of the formation.

 

Keywords: Ultrasonography; Major Salivary Gland Tumors; Pleomorphic Adenoma

References

  1. Thompson LDR and Bishop JA. “Head and neck pathology”. 3rd Philadelphia: Elsevier (2019).
  2. Cancer Research UK. Salivary gland cancer (2019).
  3. Lin HH., et al. “Current state of knowledge on salivary gland cancers”. Critical Reviews in Oncogenesis 23 (2018): 139-151.
  4. Mlika M., et al. “Salivary duct carcinoma of the parotid gland”. Journal of Oral and Maxillofacial Pathology1 (2012): 134-136.
  5. Valstar MH., et al. “Salivary gland pleomorphic adenoma in The Netherlands: a nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence”. Oral Oncology 66 (2017): 93-99.
  6. Speight PM and Barrett AW. “Salivary gland tumours: diagnostic challenges and an update on the latest WHO classification”. Diagnostic Histopathology4 (2020): 147-158.
  7. Hellquist HB and Skalova A. “Histopathology of the salivary glands”. Berlin: Springer-Verlag (2014).
  8. World Health organization classification of head and neck tumours. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Sootweg P, editions. Tumours of the salivary glands”. 4th Lyon IARC press (2017): 159e202.
  9. Khurrram SA., et al. “Diagnostic difficulties in lesions of the minor salivary glands”. Diagn Histopathology 23 (2017): 250-259.
  10. Stenman G. “Fusion oncogenes in salivary gland tumors: molecular and clinical consequences”. Head and Neck Pathology1 (2013): S12-19.
  11. Seethala RR and Stenman G. “Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland”. Head and Neck Pathology 11 (2017): 55-67.
  12. Khurram SA., et al. “Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 122 (2016): 731-742.
  13. Skalova A., et al. “Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity”. The American Journal of Surgical Pathology5 (2010): 599-608.
  14. Xu B., et al. “Pan-Trk immunohistochemistry is a sensitive and specific ancillary tool in diagnosing secretory carcinoma of salivary gland and detecting ETV6-NTRK3 fusion”. Histopathology (2019).
  15. Chiosea SI., et al. “The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma”. The American Journal of Surgical Pathology3 (2012): 343-350.
  16. Bishop JA., et al. “Most nonparotid “acinic cell carcinomas” represent mammary analog secretory carcinomas”. The American Journal of Surgical Pathology7 (2013): 1053-1057.
  17. Tessy PJ., et al. “Fine needle aspiration cytology of salivary gland lesions with histopathological correlation:A two year study”. International Journal of Healthcare and Biomedical Research4 (2015): 91-99.
  18. Enescu AS., et al. “The involvement of growth differentiation factor 5 (GDF5) and aggrecan in the epithelial– mesenchymal transition of salivary gland pleomorphic adenoma”. Romanian Journal of Morphology and Embryology4 (2013): 969-976.
  19. Welkoborsky HJ. “Current aspects in ultrasonography of the salivary glands”. HNO2 (2011): 155-165.
  20. Abdullaev RYa. “Sialosis Cytomorphological significance in the diagnosis of an uncommon entity”. EC Dental Science1 (2017): 11-19.
  21. Carotti M., et al. “Ultrasonography of the salivary glands: the role of grey-scale and colour/power Doppler”. Clinical and Experimental Rheumatology 32 (2014): S61-70.
  22. Sood S., et al. “Management of Salivary Gland Tumours: United Kingdom National Multidisciplinary Guideline”. Journal of Laryngology and Otology2 (2016): S142-S149.
  23. Jeong WJ., et al. “Fine needle aspiration of parotid tumors: diagnostic utility from a clinical perspective”. Journal of Oral and Maxillofacial Surgery7 (2013): 1278-1282.
  24. Ramirez-Perez F., et al. “Is fine-needle aspiration a reliable tool in the diagnosis of malignant salivary gland tumors?” The Journal of Cranio-Maxillofacial Surgery7 (2017): 1074-1077.
  25. Abd El-latif Ibrahim El-Rasheedy., et al. “The role of ultrasound in evaluating salivary glands swellings”. The Egyptian Journal of Otolaryngology 37 (2021): 101.
  26. Kakoty S., et al. “FNAC and histopathological correlation of salivary gland lesions: An observational study”. International Journal of Surgery7 (2017): 2148-2152.
  27. Anto J Richie and Mellonie P. “Sonological evaluation of major salivary gland lesions with histopathological correlation”. International Journal of Contemporary Medicine Surgery and Radiology2 (2019): B91-B94.
  28. Bozzato A., et al. “Potential of ultrasound diagnosis for parotid tumors: analysis of qualitative and quantitative parameters”. Otolaryngology-Head and Neck Surgery4 (2007): 642-646.
  29. Wu S., et al. “Role of ultrasound in the assessment of benignity and malignancy of parotid masses”. Dentomaxillofacial Radiology2 (2012): 131-135.
  30. Vijai Pratap SK Jain. "Sonographic Evaluation of Salivary Gland Tumors – A Hospital Based Study". International Journal of Scientific Study4 (2014): 32-36.
  31. Chandak R., et al. “An evaluation of efficacy of ultrasonography in the diagnosis of head and neck swellings”. Dentomaxillofacial Radiology4 (2011): 213-221.
Citation: Rizvan Ya Abdullaiev., et al. “Ultrasound Diagnosis of Major Salivary Gland Tumors”. EC Dental Science 21.7 (2022): 57-68.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


September Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the September issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before October 14, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.