Research Article
Volume 21 Issue 9 - 2022
Effect of Local Administration of Clodronate on Bone Density After Orthodontic Treatment
Neam F Agha1* and Khalid K Alghabsha2
1Assistant Professor, Department of Pedodontic, Orthodontic, and Preventive Dentistry, College of Dentistry, Mosul University, Mosul, Iraq
2Lecturer, Department of Physiology, College of Medicine, Ninavah University, Iraq
*Corresponding Author: Neam F Agha, Assistant Professor, Department of Pedodontic, Orthodontic, and Preventive Dentistry, College of Dentistry, Mosul University, Mosul, Iraq.
Received: September 11, 2021; Published: August 09, 2022


Aim: The aim of this research was to evaluate the local effect of clodronate on created space done by orthodontic teeth movement on rabbits teeth.

Materials and Methods: A twenty local rabbits of age 6 months to two years, their weight about 1,25 - 1,75 Kg. The rabbits grouped into control, and experimental group with sub-grouping into 2 and 3-weeks, 5 rabbits for each group. The appliance fixed on lower incisors of the animal. Clodronate is drug that given locally at the mesial side of incisors. Testing of the animals were done by body-dual-energy x-ray densitometer, tissue assessment for the number of osteoblast and osteoclast for all the groups with hematoxylin and eosin stain.

Results: High mean value in bone density test for experimental group, with significant difference found between it and control groups of same period. Cell numbers (osteoblast) are higher in 2nd than 3rd week period for both groups, and higher value found in experimental group than control one. A non-significant differences for osteoclast number found among the sub-groups.

Conclusion: Local clodronate is effective in reducing the unwanted tooth movements by increasing the density of bone thus reduce relapse. Best advantage of clodronate was seen in third week of retention after drug withdrawal.


Keywords: Local Administration; Clodronate; Bone Density; DXA; Relapse


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Citation: Neam F Agha and Khalid K Alghabsha. “Effect of Local Administration of Clodronate on Bone Density After Orthodontic Treatment”. EC Dental Science 21.9 (2022): 01-11.

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