Editorial
Volume 5 Issue 1 - 2021
Blood Microbiome Role in Diabetes, Obesity, and Cardiovascular Diseases
Amr TM Saeb*
College of Medicine, King Saud University, KSA
*Corresponding Author: Amr TM Saeb, College of Medicine, King Saud University, KSA.
Received: January 05, 2021; Published: December 31, 2020




"Blood is an exceptional juice," said Johann Wolfgang von Goethe, the German writer and statesman. For more than three hundred years, blood was considered a sterile and immensely immunologically protected environment, and that any presence of microbes in the blood is only associated with an infectious disease. However, this concept was negated over the past decade by several lines of evidence reporting the presence of the blood microbiota and their cellular components and product. In fact, in the mid-20th century, some bacterial species were detected using traditional culturing techniques in healthy individuals' blood. Subsequently, bacterial, viral, bacteriophages, archaea, and some fungal (Basidiomycota and Ascomycota) DNA molecules were detected using both Sanger and next-generation sequencing techniques in the blood of both healthy and diseased individuals. However, the presence of living microbes and their cellular components in blood emphasized their influence on host immune and on their possible role in inducing chronic systemic inflammation associated with obesity, diabetes, and cardiovascular diseases (CVD). Thus, numerous microbial taxa can reside in host blood, but few can turn invasive and establish pathogenic diseases. Microbes can reach the host's blood through several suggested entry points such as maternal source, i.e. placenta, amniotic fluid, injuries, infections, obliteration of cellular tight junctions, and permeability of barriers. Moreover, the oral cavity can also be an essential entry point to oral microbiome components into the bloodstream during periodontitis.

References

Citation: Amr TM Saeb. “Blood Microbiome Role in Diabetes, Obesity, and Cardiovascular Diseases”. EC Diabetes and Metabolic Research 5.1 (2021): 29-31.

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