Research Article
Volume 5 Issue 3 - 2021
‘Therapeutic Polymorphism’ of Anti-Diabetic Herbal Drug
Amruthavalli GV*, Aruna V and Gayathri R
Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Kunrathur, Chennai, India
*Corresponding Author: Amruthavalli GV, Assistant Manager, Dr. JRK’s Research and Pharmaceuticals Pvt Ltd, Kunrathur, Chennai, India.
Received: February 22, 2021; Published: February 25, 2021




Abstract

In the present paper, we have unveiled the science behind herbal medicine and have established the therapeutic polymorphism exerted by different phyto-active molecules in each herb in the formulation prepared with multiple herbs. The therapeutic benefits that we have established for a formulation were creatine degradation, degradation of creatinine and sarcosine. Further we have also studied the effect of the formulation on neuroblast cells and kidney cells. The findings clearly show that different phyto-active constituents in the herbs exhibit different therapeutic benefits which are in several occasions, bi, tri or quadri-polar in nature. Our study clearly suggests that the polyherbal formulations may be more advantageous for treating problems like diabetes mellitus and other auto immune disorders because all such disorders by itself and also by acting as the key predilecting factor for various complications can harm the host. Details are presented in the paper.

Keywords: Diabetes Mellitus; Co-Morbidities of Diabetes; DCoD

References

  1. Kishan Gopal Ramawat., et al. “The Chemical Diversity of Bioactive Molecules and Therapeutic Potential of Medicinal Plants”. Chapter 2 (2008): 15.
  2. Ramawat KG. “Secondary metabolites in nature”. In: Ramawat KG, Merillon JM (eds) Biotechnology: Secondary Metabolites”. Science Publishers, Enfield, CT (2007): 21.
  3. Kawahito S., et al. “Problems associated with glucose toxicity: role of hyperglycemia-induced oxidative stress”. World Journal of Gastroenterology 33 (2009): 4137-4142.
  4. M Loredana Marcovecchio. “Complications of Acute and Chronic Hyperglycemia” (2017): 1-5.
  5. Nugroho AE., et al. “Pancreatic effect of andrographolide isolated from Andrographis paniculata (Burm. f.) Nees”. Pakistan Journal of Biological Sciences 1 (2014): 22-31.
  6. Claudio Coimbra Teixeira., et al.Syzygium cumini (L.) Skeels in the Treatment of Type 2 Diabetes”. Diabetes Care12 (2004): 3019-3020.
  7. Rohit Sharma., et al. “Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: critical appraisal and role in therapy”. Asian Pacific Journal of Tropical Biomedicine1 (2015): 68-78.
  8. Rufine Fachinan., et al. “Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T-Cell Cytokines”. Evidence-Based Complementary and Alternative Medicine (2017): 8.
  9. Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats”. Pharmaceutical Biology 1 (2017): 758-765.
  10. Hong Hanh Thi Tran., et al. “Inhibitors of αglucosidase and α-amylase from Cyperus rotundus”. Pharmaceutical Biology 1 (2014): 74-77.
  11. Araujo AJS., et al. “Effect of Ginger (Zingiber officinale) Supplementation on Diabetes: An Update”. American Journal of Phytomedicine and Clinical Therapeutics 3 (2018): 13.
  12. Uddandrao VVS., et al. “Evaluation of the Antioxidant and Antidiabetic Potential of the Poly Herbal Formulation: Identification of Bioactive Factors”. Cardiovascular and Hematological Agents in Medicinal Chemistry 2 (2020): 111-123.
  13. Mohan Patil., et al. “Anti-oxidant, anti-inflammatory and anti-cholinergic action of Adhatoda vasica Nees contributes to amelioration of diabetic encephalopathy in rats: Behavioral and biochemical evidences”. International Journal of Diabetes in Developing Countries1 (2013).
Citation: Amruthavalli GV., et al. “‘Therapeutic Polymorphism’ of Anti-Diabetic Herbal Drug”. EC Diabetes and Metabolic Research 5.3 (2021): 22-31.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


September Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the September issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before October 06, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.