Research Article
Volume 5 Issue 4 - 2021
Estimated HbA1c as an Index for Diabetes and Prediabetes Screening
Valeh Mirzazade*, Sadagat Sultanova, Aygun Aliyeva, Aygun Huseynova, Sevil Ismayilova and Nargiz Huseynova
Department of Therapy, Azerbaijan State Advanced Training Institute for Doctors Named After A. Aliyev, Azerbaijan
*Corresponding Author: Valeh Mirzazade, Head of the Department of Therapy, Azerbaijan State Advanced Training Institute for Doctors Named After A. Aliyev, Azerbaijan.
Received: March 18, 2021; Published: March 29, 2021




Abstract

Purpose: Different questionnaires have been suggested for the screening of diabetes mellitus. Values of these questionnaires for prediabetes screening is not clear. The aim of this study was to develop a new indicator-estimated value for screening HbA1c (ScrHbA1c), for diabetes mellitus and prediabetes screening.

Methods: 182 persons (46 men and 136 women) aged 20 - 79 years were examined by using questionnaires for diabetes, anthropometry, and blood pressure determination. A 2-hour glucose tolerance test (75g of glucose) was performed. The HbA1C examined by the SDA1c Care (SD biosensor, Korea). Fasting and post load venous plasma glucose was determined by Precision PCx Medi Sense (Abbot, USA). Anamnesis score, age, waist circumference, systolic and diastolic blood pressure was used in the calculation of the ScrHbA1c index by multiple linear regression method. Chi-square tests were applied to compare categorical variables. Qualitative characteristics of the diagnostic test as Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value, Overall Diagnostic Accuracy and Youden Index were used for the evaluation of cut-off point for ScrHbA1c index.

Results: There was statistically significant correlation (p < 0.001 in all cases) between the real HbA1c and ScrHbA1 in training group (n = 91; r = 0.5462), as in control group (n = 91; r = 0.5140) and in total study group (n = 182; r = 0.5245). The ScrHbA1c values in the training group and in the control group were significantly higher (p < 0.001 in both cases) in individuals with impaired glucose metabolism (Diabetes + Prediabetes) than in individuals without normal glucose metabolism. The values of the ScrHbA1c index did not significantly differ when comparing individuals with normal glucose metabolism (or impaired glucose metabolism) in training group and in control group (p < 0.05).

Conclusion: The new indicator - Estimated value for screening HbA1c named ScrHbA1c has been developed to select individuals who need to be screened for diabetes and prediabetes. The use of the cut-off point 44 mmol/mol allows to identify 100% of patients with diabetes mellitus, 69.6% of prediabetes cases and requires examination of 20% persons without carbohydrate metabolism disorders.

 

Keywords: Estimated Value for Screening HbA1c Index; Prediabetes; Diabetes Mellitus; Questionnaires; Screening

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Citation: Valeh Mirzazade., et al. “Estimated HbA1c as an Index for Diabetes and Prediabetes Screening”. EC Diabetes and Metabolic Research 5.4 (2021): 04-12.

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