Research Article
Volume 5 Issue 4 - 2021
Relationship of Serum Interleukin-6, Malondialdehyde and Cholesteryl Ester Transfer Protein in Patients with Metabolic Syndrome
Kyi Soe Tun1, Khin Win Sein2* and Thet Thet Swe3
1Assistant lecturer, Department of Biochemistry, University of Pharmacy, Mandalay, Myanmar
2Former Professor and Head of Department of Biochemistry, University of Medicine, Mandalay, Rector, University of Nursing, Mandalay, Myanmar
3Associate Professor, Department of Biochemistry, University of Medicine, Mandalay, Myanmar
*Corresponding Author: Khin Win Sein, Former Professor and Head of Department of Biochemistry, University of Medicine, Mandalay, Rector, University of Nursing, Mandalay, Myanmar.
Received: March 29, 2021; Published: March 31, 2021




Abstract

Metabolic Syndrome (MetS) is a major health burden throughout the world because of its high prevalence and risk of atherosclerosis and cardiovascular disease (CVD). The present study was aimed to find out the relationship of serum Cholesteryl Ester Transfer Protein (CETP), with interleukin-6 (IL-6) and malondialdehyde (MDA) as the contributory factors to dyslipidemia in patients with Metabolic Syndrome (MetS). The cross-sectional comparative study was conducted at the Outpatient Department (OPD) of medical units in Mandalay General Hospital. The clinically diagnosed cases of metabolic syndrome (n = 40) who attended to OPD of medical unit in Mandalay General Hospital were categorized as patients with metabolic syndrome according to National Cholesterol Education Program (Adult Treatment Panel [ATP] III) (2001). An apparently healthy volunteers (n = 40) who were staffs of University of Medicine Mandalay participated as controls in this study. Serum IL-6 and serum CETP levels were determined by sandwich enzyme linked immunosorbent assay (ELISA). Serum MDA level was determined by colorimetric method based on a thiobarbituric acid reacting substances (TBARS) assay.

The mean level of serum IL-6 (30.25 21.58 pg/mL) and MDA levels (10.999.54 mmol/L) were significantly higher in MetS patients than that of controls, p < 0.0001. The serum IL-6 level was positively associated with MDA level in MetS patients (r = 0.86), p < 0.0001 and in controls (r = 0.44) p < 0.0001, respectively.

The mean serum CETP level was significantly higher in MetS patients (4.860.83 mg/mL) compared to controls (1.471.13 mg/mL), p < 0.0001. There was a strong positive correlation between IL-6 and CETP level in both controls (r = 0.73) p < 0.0001 and MetS patients (r = 0.62) (p < 0.0001).

The present study indicated that serum IL-6, MDA and CETP levels were found to be higher in patients with MetS than in controls. The inflammatory cytokine especially IL-6 and oxidative stress marker, MDA was positively associated with serum CETP considered as a marker for dyslipidemia in MetS as the high CETP level may reflect reduced HDL-C and reduced LDL particle.

In conclusion, present data indicated that the release of inflammatory cytokine especially IL-6 and oxidative stress marker, MDA were found to be associated with serum CETP contributing to dyslipidemia as one of the components of MetS. However, these markers could not be considered as contributory factor to metabolic syndrome (MetS).

Keywords: Cardiovascular Disease (CVD); Cholesteryl Ester Transfer Protein (CETP); Interleukin-6 (IL-6); Malondialdehyde (MDA); Outpatient Department (OPD); Adult Treatment Panel (ATP); Enzyme Linked Immunosorbent Assay (ELISA); Thiobarbituric Acid Reacting Substances (TBARS); Metabolic Syndrome (MetS)

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Citation: Khin Win Sein., et al. “Relationship of Serum Interleukin-6, Malondialdehyde and Cholesteryl Ester Transfer Protein in Patients with Metabolic Syndrome”. EC Diabetes and Metabolic Research 5.4 (2021): 71-81.

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