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Mini Review
Volume 5 Issue 2 - 2020
The I0*G60, a New Kid on the Block
Patricio H Contreras1,2*, Yanara A Bernal1 and Pilar Vigil1,2,3
1Fundación Médica San Cristóbal, Santiago, Chile
2 Reproductive Health Research Institute (RHRI), Santiago, Chile
2Vicerrectoría de Comunicaciones, Pontificia Universidad Católica de Chile
*Corresponding Author: Patricio H Contreras, Reproductive Health Research Institute (RHRI), Santiago, Chile.
Received: : January 13, 2020; Published: January 31, 2020




Abstract

In this Minireview we describe how, in the process of finding the appropriate diagnostic cutoffs for several traditional biochemical predictors of insulin resistance, we found that the product of the fasting insulin value (I0) times the glucose value at 60 min of the OGTT (G60) predicted insulin resistance. Moreover, it did so more efficiently than the traditional predictors of insulin resistance (HOMA, the QUICKI, and the ISI-OL). The new predictor was labelled as the I0*G60. Its area under the ROC curve against the Steady State Plasma Glucose (SSPG) value of the Pancreatic Suppression Test was 0.867, higher than the respective value of the ISI-OL (0.835), the best performing of the traditional biochemical predictors of insulin resistance. The sensitivity rose from 0.811 (ISI-OL) to 0.865 (I0*G60). The cutoff for the new predictor suggesting insulin resistance was > 428.2 mMol/L*pMol/L (> 1,110 mg/dL*mU/L). The ROC Curve analysis-defined cutoff against the SSPG of the traditional predictors improved notoriously the sensitivity of these tests when compared with the commonly used cutoffs. The HOMA and the QUICKI had similar diagnostic performances. The ISI-OL and the I0*G60 had a strong non-linear mathematical relationship (r > 0.9). A simple OGTT with 3 glucose values (0-60-120 min) and a single insulin value (0 min) would allow the proper categorization of a patient, both in terms of glucose tolerance and insulin sensitivity status. The I0*G60 is simple to perform, inexpensive, and easily calculable.

Keywords: Insulin Resistance; Biochemical Predictors of Insulin Resistance; I0*G60; Matsuda-DeFronzo’s ISI Composite; HOMA

References

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Citation: Patricio H Contreras., et al. “The I0*G60, a New Kid on the Block”. EC Endocrinology and Metabolic Research 5.2 (2020): 01-06.

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