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Research Article
Volume 5 Issue 2 - 2020
Role of Inflammation on the Control of the Arterial Hypertension among Patients with Metabolic Syndrome
Ylber Jani1*, Atila Rexhepi2, Bekim Pocesta3, Ahmet Kamberi4, Fatmir Ferati2, Sotiraq Xhunga5, Artur Serani5, Dali Lala6, Agim Zeqiri7, Arben Mirto8 and Lutfi Zylbeari1
1Faculty of Medicine, Tetovo, Republic of North Macedonia
2Department of Internal Medicine, Faculty of Medicine, Tetovo, Republic of North Macedonia
3Department of Cardiology, Faculty of Medicine, “Ss Kiril and Metodij” University, Skopje, Republic of North Macedonia
4Department of Cardiology, Faculty of Medicine, M. Teresa Tirana, Republic of Albania
5Department of Cardiology, Medical Center Dures, Republic of Albania
6Private Health Institute of Family Medicine “Florenc”, Tetovo, Republic of North Macedonia
7Department of Internal Medicine, General Hospital “DR Ferit Murat” Gostivar, Republic of North Macedonia
8Private Health Institute, “Rostusha” Debar, Republic of North Macedonia
*Corresponding Author: Ylber Jani, Faculty of Medicine, Tetovo, Republic of North Macedonia
Received: January 08, 2020; Published: January 31, 2020




Abstract

Background: It is widely accepted that hypertension is a pro-inflammatory disease and that the immune system plays a vital role in mediating hypertensive outcomes, end organ damages and modulation of hypertensive pathology [2]. Patient with MetS usually present increased levels of C-reactive protein (CRP) which is a prototypic marker of inflammation [5], however the data of the influence of increased levels of CRP on the control of the arterial hypertension in patients with MetS, are scarce.

Objective: We sought to determine the increased CRP levels influence on the control of the arterial hypertension in patients with MetS.

Methods: We conducted a multicenter observational cross-sectional study. The study population recruited from a couple of outpatient clinic between June 2018 and June 2019. The population study consisted of 420 patients with MetS aged ≥ 18 years, divided in two groups: 211 with level of CRP > 3 mg/l and 209 participants with CRP level < 3 mg/l.

Results: Among those with CRP level > 3 mg/l (N = 211) controlled BP according to evidence and current guidelines, was achieved in 23.6% of participants, whereas among those with CRP level < 3 mg/l (N = 209) controlled BP was achieved in 48.3%; p = 0.000). There was independent association of CRP levels > 3 mg/l with uncontrolled BP (OR = 3.1, 95%CI 2.06 - 4.75). There were significant association of uncontrolled BP with: uncontrolled glycemia (OR = 1.4, 95%CI 0.97 - 1.84); increased BMI (OR = 4.4; 95%CI 3.02 - 4.05) and five risk factors for MetS (OR = 2.3, 95%CI 1.93 - 2.81).

Conclusion: We think, we brought some good evidence, in our present study, that patients with MetS and higher CRP level have a higher prevalence of uncontrolled BP.

Keywords: C-Reactive Protein; Control of BP in Patient with Metabolic Syndrome

References

  1. “Heart Disease and Stroke Statistics-2019. Update: a report from the American Heart Association”. Circulation 139 (2019): e56-528.
  2. Tomasz P., et al. “Adaptive Immunity in Hypertension”. Current Hypertension Reports 21 (2019): 68.
  3. Ford ES. “Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation among adults in the U.S”. Diabetes Care 28.11 (2005): 2745-2749.
  4. Ford ES., et al. “Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US”. Journal of Diabetes 2.3 (2010): 180-193.
  5. Haffner SM. “The metabolic syndrome: inflammation, diabetes mellitus and cardiovascular disease”. The American Journal of Cardiology 97.2A (2006): 3A-11A.
  6. Bryan Williams., et al. “2018 ESC/ESH Guidelines for the management of arterial hypertension”. European Heart Journal 39.33 (2018): 3021-3104. 
  7. America Diabetes Association. “Standards for medical care for patient with diabetes mellitus”. Diabetes Care 25.1 (2002): S33-S49.
  8. Center for disease control/American Heart association Workshop on inflammatory Markers, and Cardiovascular Disease: Application to clinical and public health practice: Atlanta, Ga. Centers for Disease Control and Prevention (2002).
  9. Ford ES., et al. “Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US”. Journal of Diabetes 2.3 (2010): 180-193.
  10. Organisation WH. “Waist circumference and waist -hip ratio: report of WHO expert consultation”. Geneva (2008): 8-11.
  11. Guzik TJ., et al. “Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction”. Journal of Experimental Medicine 204 (2007): 2449-2460.
  12. Pruijm M., et al. “Inflammatory markers and blood pressure: sex differences and the effect of fat mass in the CoLaus Study”. Journal of Human Hypertension 27 (2013): 169-175.
  13. Sesso HD., et al. “C-reactive protein and the risk of developing hypertension”. Journal of American Medicine Association 290 (2003): 2945-2951.
  14. Grundy SM. “Inflammation, hypertension, and the metabolic syndrome”. Journal of American Medicine Assocaition 290.22 (2003): 3000-3002.
  15. Smith GD., et al. “Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality”. Arteriosclerosis, Thrombosis, and Vascular Biology 25 (2005): 1051-1056.
  16. Kjeldsen SE., et al. “Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the global cardiometabolic risk profile in patients with hypertension disease survey”. Journal of Hypertension 26 (2008): 2064-2070.
  17. Jani Y., et al. “Control of Arterial Hypertension among type-2 Diabetics”. International Journal of Biomedicine 3.4 (2013): 232-239.
  18. Arcucci O. et al. “Association of suboptimal blood pressure control with body size and metabolic abnormalities”. Journal of Hypertension 25 (2007): 2296-2300. 
  19. Garcia VP., et al. “Sex differences in High Sensitive C-Reactive Protein in subjects with Risk Factors of Metabolic Syndrome”. Arqquivos Brasileiros Cardiologia 106.3 (2016): 182-187.
  20. Ridker PM., et al. “Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk?”. Circulation 109 (2004): 2818-2825.
  21. Sandhu HS., et al. “A Study of Correlation between Lipid Profile and Body Mass Index (BMI) in Patients with Diabetes Mellitus”. Journal of Human Ecology 24 (2008): 227-229.
  22. Matsuda M and Shimomura I. “Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer”. Obesity Research and Clinical Practice 7 (2013): E330-E341.
Citation: Ylber Jani., et al. “Role of Inflammation on the Control of the Arterial Hypertension among Patients with Metabolic Syndrome”. EC Endocrinology and Metabolic Research 5.2 (2020): 01-07.

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