Welcoming you for any type of article submission for the upcoming issue on/before February 26, 2021.


Mini Review
Volume 5 Issue 4 - 2020
Senescence and Diabetes
Nabil Kamal Elnaggar1* and Mohamed Nabil Elnaggar2
1Diabetes, Obesity and Endocrinology Center, HaiAljamea Hospital, Jeddah, Kingdom of Saudi Arabia
2Department of Endocrinology, Diabetes and Metabolism, University Hospitals of Morecambe Bay NHS Foundation Trust, Lancaster, United Kingdom
*Corresponding Author: Nabil Kamal Elnaggar, Diabetes, Obesity and Endocrinology Center, HaiAljamea Hospital, Jeddah, Kingdom of Saudi Arabia.
Received: February 22,2020; Published: March 16, 2020




It has long been the dream of humanity to regain youth and defeat aging. Research tried for decades to explore the mechanisms of aging and possible ways to intervene therapeutically in order to delay/prevent aging. Senescence is one of the processes by which aging cells can invoke deleterious effects on other cells and remote organs. Cellular senescence could be the missing link between aging and related chronic diseases including diabetes and cardiovascular diseases. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. In this mini-review, we summarize current knowledge on cellular senescence and its secretory phenotype and their mechanistic role, that may help identify potential drug targets for age-related diseases, and treating them as a group, rather than one at a time thereby facilitating healthful life span extension in humans.

Keywords: Senescence; Diabetes; Cardiovascular Diseases

References

  1. Tamara Tchkonia., et al. “Cellular senescence and the senescent secretory phenotype: therapeutic opportunities”. Journal of Clinical Investigation 123.3 (2013): 966-972. 
  2. Rafael de Cabo., et al. “Effects of Intermittent Fasting on Health, Aging, and Disease”. New England Journal of Medicine 381.26 (2019): 2541-2551.
  3. Kapahi P., et al. “With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging”. Cell Metabolism 11.6 (2010): 453-465. 
  4. Olshansky SJ., et al. “In search of Methuselah: estimating the upper limits to human longevity”. Science 250.4981 (1990): 634-640.
  5. Demaria M., et al. “An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA”. Developmental Cell 31.6 (2014): 722-733. 
  6. Jun J-I and Lau LF. “The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing”. Nature Cell Biology 12.7 (2010): 676-685. 
  7. Muñoz-Espín D., et al. “Programmed cell senescence during mammalian embryonic development”. Cell 155.5 (2013): 1104-1118.
  8. Hadis S., et al. “Cellular senescence links aging and diabetes in cardiovascular disease”. American Journal of Physics 315.3 (2018): 448-462.
  9. RISE Consortium. “Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp”. Diabetes Care 41.8 (2018): 1696-1706. 
  10. Gu J., et al. “Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis”. Cell Death and Disease 9.2 (2018): 82. 
  11. Katsuumi G., et al. “Vascular senescence in cardiovascular and metabolic diseases”. Frontiers in Cardiovascular Medicine 5 (2018): 18. 
  12. Fiordaliso F., et al. “Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death”. Diabetes 50.10 (2001): 2363-2375. 
  13. Shakeri H., et al. “Neuregulin-1 attenuates stress-induced vascular senescence”. Cardiovascular Research 114.7 (2018): 1041-1051. 
  14. Matsushita H., et al. “eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization”. Circulation Research 89.8 (2001): 793-798. 
  15. Gevaert AB., et al. “Endothelial senescence contributes to heart failure with preserved ejection fraction in an aging mouse model”. Circulation: Heart Failure 10.6 (2017): e003806. 
  16. Lakatta EG. “So! What’s aging? Is cardiovascular aging a disease?” Journal of Molecular and Cellular Cardiology 83 (2015): 1-13. 
  17. Palmer and Associates. “Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity”. Diabetes 64.7 (2015): 2289-2298.
  18. Moiseeva O., et al. “Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kB activation”. Aging Cell 12.3 (2013): 489-498.
  19. Minamino T., et al. “Akt-induced cellular senescence: implication for human disease”. Cell Cycle 3.4 (2004): 449-451.
  20. LJ Hickson., et al. “Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease”. EBioMedicine 47 (2019): 446-456.
  21. Yabing Xiong and Lili Zhou. “The Signaling of Cellular Senescence in Diabetic Nephropathy”. Oxidative Medicine and Cellular Longevity (2019): 7495629.
  22. N Tasdemir., et al. “BRD4 connects enhancer remodeling to senescence immune surveillance”. Cancer Discovery 6.6 (2016): 612-629.
  23. Peter J., et al. “Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes”. Cell Metabolism 29.5 (2019): 1045-1060.
  24. Palmer K., et al. “Targeting senescent cells alleviates obesity‐induced metabolic dysfunction”. Aging Cell 18.3 (2019): e12950. 
  25. Ogrodnik., et al. “Cellular senescence drives age-dependent hepatic steatosis”. Nature Communications 8 (2017): 15691. 
  26. Roos M., et al. “Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice”. Aging Cell 15.5 (2016): 973-977. 
  27. Yi Zhu., et al. “New agents that target senescent cells: the flavone, fisetin, and the BCL‐XL inhibitors, A1331852 and A1155463”. Aging 9.3 (2017): 955-963.
  28. Stroissnigg HF., et al. “Identification of HSP90 inhibitors as a novel class of senolytics”. Nature Communications 8.1 (2017): 422.
  29. Malavolta M., et al. “Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy”. Mediators of Inflammation (2018): 4159013. 
Citation: Nabil Kamal Elnaggar and Mohamed Nabil Elnaggar. “Senescence and Diabetes”. EC Endocrinology and Metabolic Research 5.4 (2020): 03-08.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


June Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the June issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before June 25, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk