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Review Article
Volume 5 Issue 5 - 2020
Subclinical Hypothyroidism: The Neglected Thyroid Dysfunction (Review)
Salem Bouomrani1,2*
1Department of Internal Medicine, Military Hospital of Gabes, Gabes, Tunisia
2Sfax Faculty of Medicine, University of Sfax, Sfax, Tunisia
*Corresponding Author: Salem Bouomrani, Department of Internal Medicine, Military Hospital of Gabes, Gabes, Tunisia.
Received: February 28, 2019; Published: April 23, 2020


With a global prevalence estimated at 4 - 10.5%, subclinical hypothyroidism (SCH) is the most frequent thyroid dysfunction but remains neglected and often under-diagnosed. It is defined by an increase in thyroid stimulating hormone (TSH) level with a normal free total thyroxin (FT4) and absence of specific clinical manifestations of thyroid hormone deficiency.

It has been recently demonstrated that this thyroid dysfunction is associated to a markedly increased cardiovascular risk, significant increase in all-cause mortality, and specific cardiovascular mortality.

This entity remains, however, too controversial in terms of clinical diagnosis, biological thresholds, prognostic implications, and therapeutic management.

The purpose of this review is to familiarize health professionals with the different aspects of this thyroid dysfunction: epidemiology, etiology, natural history, and management.

Keywords: Subclinical Hypothyroidism; Hypothyroidism; Thyroid Gland; Thyroid Dysfunction; Endocrinopathy


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Citation: Salem Bouomrani. “Subclinical Hypothyroidism: The Neglected Thyroid Dysfunction (Review)”. EC Endocrinology and Metabolic Research 5.5 (2020): 23-30.

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