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Editorial
Volume 5 Issue 11 - 2020
Obesity and Immunometabolism: Nutritional Consideration to Covid Times
Carmine Finelli1,2*
1Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy
2Covid Hospital Boscotrecase - ASL Napoli 3 Sud, Via Lenza, Boscotrecase, Napoli, Italy
*Corresponding Author: Carmine Finelli, Department of Internal Medicine, Ospedale Cav. R. Apicella - ASL Napoli 3 Sud, Via di Massa, Pollena, Napoli, Italy.
Received: September 25, 2020; Published: October 03, 2020




Nutritional intervention in obesity usually appears to concentrate exclusively on lowering weight without taking into account an appropriate approach for the metabolic disorders involved in oxidative stress and inflammation. Further than weight, functional nutrition therapy in people with obesity requires the evaluation of dysbiosis, oxidative stress and chronic inflammatory status to incorporate dietary interventions using precise doses of antioxidant, anti-inflammatory and immunomodulatory bioactive compounds [1].

Recently, elderly people and people of all ages who may have serious underlying health problems, combined with obesity, may be at high risk from COVID-19 for severe illness. Because it is still soon to include solid evidence to confirm this in this pandemic, it is reasonable to think that some patients with obesity will have many obesity-related health problems that may be associated with a more severe path of COVID-19 disease, particularly extreme obesity with a body mass index over 40 [2]. In the intensive care environment, patients with severe obesity are usually more difficult to treat demographically, and may fail to recover if they experience some serious illness, especially respiratory infections such as COVID-19. Not a solution to COVID-19, but healthy eating habits enhance the activity of the immune system, promote immunometabolism, and are a modifiable component of chronic disease development closely correlated with COVID-19 deaths [3,4]. In the inherent immune response to infection, regulation of immune cell bioenergetics and metabolic capacity plays a central role, and as we seek to tackle this current global health threat, the innate immune system’s immunometabolism warrants attention [5].

References

  1. Boccellino M and D'Angelo S. “Anti-Obesity Effects of Polyphenol Intake: Current Status and Future Possibilities”. International Journal of Molecular Sciences 16 (2020): 5642.
  2. Finelli C. “Obesity and Covid 19: Possible Risks!”. EC Endocrinology and Metabolic Research 6 (2020): 01-03.
  3. Finelli C. “Nutrition and Covid-19: State of the Art”. EC Endocrinology and Metabolic Research 9 (2020): 21-23.
  4. Finelli C. “Obesity COVID-19 and immunotherapy: the complex relationship!” Immunotherapy (2020).
  5. Gleeson LE., et al. “COVID-19 and innate immunometabolism”. British Journal of Nutrition 7 (2020): 1-5.
  6. Zabetakis I., et al. “COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation”. Nutrients5 (2020): 1466.
  7. Morais AHA., et al. “Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?” Nutrients 6 (2020): 1737.
  8. Jaggers GK., et al. “COVID-19: repositioning nutrition research for the next pandemic”. Nutrition Research 81 (2020): 1-6.
  9. Manna P and Jain SK. “Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies”. Metabolic Syndrome and Related Disorders 10 (2015): 423-444.
  10. García-Sánchez A., et al. “The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity”. Diabetes, Metabolic Syndrome and Obesity 13 (2020): 1077-1087.
  11. Bacchetti T., et al. “Relationship of fruit and vegetable intake to dietary antioxidant capacity and markers of oxidative stress: A sex-related study”. Nutrition 61 (2019): 164-172.
  12. Hosseini B., et al. “Association Between Antioxidant Intake/Status and Obesity: a Systematic Review of Observational Studies”. Biological Trace Element Research 2 (2017): 287-297.
  13. López-Moreno A., et al. “Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis”. Nutrients 7 (2020): 1921.
  14. Maggini S., et al. “Immune Function and Micronutrient Requirements Change over the Life Course”. Nutrients10 (2018): 1531.
  15. Noland D and Raj S. “Academy of Nutrition and Dietetics: Revised 2019 Standards of Practice and Standards of Professional Performance for Registered Dietitian Nutritionists (Competent, Proficient, and Expert) in Nutrition in Integrative and Functional Medicine”. Journal of the Academy of Nutrition and Dietetics 6 (2019): 1019-1036.
Citation: Carmine Finelli. “Obesity and Immunometabolism: Nutritional Consideration to Covid Times”. EC Endocrinology and Metabolic Research 5.11 (2020): 01-03.

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