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Review Article
Volume 5 Issue 12 - 2020
Exogenous Testosterone as a Risk Factor for Male Infertility and Recommendations for Recovery
Rashad Roberson1, Nicholas A Kerna2* and Raymond Nomel3
1Georgetown American University, College of Medicine, Guyana
2SMC–Medical Research, Thailand
3All Saints University, College of Medicine, St. Vincent and the Grenadines
*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: October 08, 2020; Published: November 25, 2020


Exogenous testosterone use is widespread in the adult male population—with or without age-related infertility or medical necessity. Exogenous testosterone compounds are readily available to the consumer. There are benefits to its indicated and supervised application; however, caution regarding its use is advised. Exogenous testosterone supplementation alters testicular biochemistry, leading to azoospermia and infertility in men, previously unaffected by age-related infertility. Also, long-term use has public health consequences in that it can increase the incidence and prevalence of prostate cancer in otherwise healthy men. Fortunately, in most men unaffected by age-related infertility, there is a return of normal spermatogenesis within one year of discontinuation of exogenous testosterone. This paper reviews and summarizes exogenous testosterone’s adverse effects on the male hypothalamic-pituitary- gonad axis, the remedy and recovery thereof, and the public health risk..

Keywords: Azoospermia; Exogenous Testosterone, Male Infertility; Spermatogenesis


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Citation: Nicholas A Kerna., et al. ““Exogenous Testosterone as a Risk Factor for Male Infertility and Recommendations for Recovery”. EC Endocrinology and Metabolic Research 5.12 (2020): 16-21.

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