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Research Article
Volume 6 Issue 3 - 2021
Epididymal Cytotoxicity and Protective Effect of Quercetin Following Epirubicin Exposure in Swiss Albino Mice
Ojo Olajumoke Omolara*
Department of Biochemistry, Faculty of Science, University Ado-Ekiti, Ekiti State, Nigeria
*Corresponding Author: Ojo Olajumoke Omolara, Department of Biochemistry, Faculty of Science, University Ado-Ekiti, Ekiti State, Nigeria.
Received: February 03, 2021; Published: February 27, 2021




Abstract

Epirubicin is an anthracycline drug used in the treatment of different cancers and in combination with other medications. Toxicity of this drug have been reported but little is known about its effect on epididymis thus, this study aimed at evaluating the possible adverse effect of epirubicin on the epididymis tissue using mouse model. Potential ameliorating effect of quercetin from onion extract was also investigated. In this study, the mice used were divided into six groups. Mice in group I received vehicle and served as control; group II-5 mg/kg/bwt/day, III-10 mg/kg/bwt & group IV- 20 mg/kg/bwt. Mice in group V received 10 mg/kg/bwt Quercetin (standard) + 20 mg/kg/bwt while group VI were co-treated with 10 mg/kg/bwt Onion extracts + 20 mg/kg/bwt for fourteen days. Activities of some vital biochemical biomarker enzymes, sperm parameters and epididymal histology were evaluated. In this study, significant (p<0.05) depletion of sperm count and motility was measured, raised ROS and MDA with simultaneous depletions of the antioxidant enzymes was evaluated. Disruption of epithelium and vacuolization were observed in the cauda epididymis. However, appreciable recovery was seen in both groups V and VI that were co-treated with either quercetin or onion extract. Conclusively, this study reports generation of oxidative stress in epididymis leading to spermotozoa cytotoxicity in epirubicin treated mice. The studies also revealed that quercetin from onion extract can help to reduce the deleterious effect of epirubicin treatment.

Keywords: Epididymal Cytotoxicity; Quercetin; Epirubicin; Swiss Albino Mice

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Citation: Ojo Olajumoke Omolara. “Epididymal Cytotoxicity and Protective Effect of Quercetin Following Epirubicin Exposure in Swiss Albino Mice”. EC Endocrinology and Metabolic Research 6.3 (2021): 17-28.

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