Research Article
Volume 7 Issue 3 - 2020
Thyroid Dysfunctions in Patients with Hepatocellular Carcinoma Treated by Transarterial Chemoembolization
Amal Tohamy Abdelmoez1*, Ahmed Abbas Elkhattib1, Amany M Maher2 and Ahmed Kamal ElDorry3
1Tropical Medicine Department, Ain Shams University, Egypt
2Medical Research Center, Molecular Biology Unit, Ain Shams University, Egypt
3Radiology Medicine, Egypt
*Corresponding Author: Amal Tohamy Abdelmoez, Assistant Professor of Tropical Medicine, Ain Shams University, Egypt.
Received: October 17, 2019; Published: February 08, 2020




Abstract

Background: Trans-arterial chemoembolization (TACE) involves the application of iodide in the form of lipiodol mixed with a chemotherapeutic agent Although required for thyroid hormone synthesis, excess intra-thyroid iodide can paradoxically decrease hormone synthesis. 

Aim: Evaluation of the thyroid dysfunctions after TACE for patients with hepatocellular carcinoma.

Patients and Methods: We included 30 patients with hepatocellular carcinoma who were eligible for TACE. We excluded patients with history of antiviral therapy, thyroid diseases and residence in iodine deficiency areas. After written consent, all patients were subjected to history taking, clinical examinations and laboratory investigations (liver profile, renal functions tests) and TSH, FT3, FT4 before TACE, one weak and one month later.

Results: After one week TSH, FT3, and FT4 levels were high in 4 patients (13.3%), 2 patients (6.7%), 5 patients (16.7%), and low in one patient (3.3%), 2 patients (6.7%),3 patients (10%) and normal in 25 patients (83.3%), 26 patients (86.7%), 22 patients (73.3%) respectively with significant difference (p < 0.05). One month later the levels were high in (0%),4 patients (13.3%),9 patients (30%) low in 3 patients (10%), one patients(3.3%), no patients (0%) and normal in 27 patients (90%), 25 patients (83.3%), 21 patients (70%) respectively with a significant difference ( < 0.05).

Conclusions: Thyroid dysfunctions after TACE presented in 16.7% of patients and could be hypo or hyper-thyroidism.

Impact: This work results are important as TACE is an important technique for treatment of hepatocellular carcinoma and can be used several times and so the risk for thyroid disorders is increased. These results recommend that patients with hepatocellular carcinoma must have their thyroid functions checked before and after TACE.

Keywords: TACE; Thyroid; Iodine

References

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Citation: Amal Tohamy Abdelmoez., et al. “Thyroid Dysfunctions in Patients with Hepatocellular Carcinoma Treated by Transarterial Chemoembolization”. EC Gastroenterology and Digestive System 7.3 (2020): 01-08.

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