Case Report
Volume 7 Issue 3 - 2020
Advanced Gastric Cancer after Two Liver and One Renal Transplantation. Case Report
Rinaldis A1, Bonini AL1, Matavelli FA1, Beron RI1, Lourenço LG2*
1Surgeon, General Surgery Division, Hospital do Rim, UNIFESP, Brazil
2Head of General Surgery Division, Hospital do Rim, UNIFESP, Brazil
*Corresponding Author: Lourenço LG, Head of General Surgery Division, Hospital do Rim, UNIFESP, Brazil.
Received: January 21, 2020; Published: February 26, 2020




Abstract

Introduction: An estimated 20% increase of malignancy incidence has been found on liver and renal transplanted populations, probably associated with long-term use of immunosuppressant agents. Therapeutic approach for these patients was often treacherous and risky. Late detection of tumors and graft related complications was a common scenario. Nowadays the transplant recipients are able to receive multiple oncologic treatments. 

Case Report: A 69-year-old male was submitted to multiple organ transplantation surgeries being those, two liver and one renal transplantations on a 16 year period. The liver transplantations were in 1994 and 1999 due to HCV infection. He remained stable until 2005 when chronic uses of immunosuppressive drugs lead him to chronic renal failure and he received a deceased donor kidney graft in 2007. Two years later, after dyspeptic symptoms, initial investigation and workup was done with EGD and abdominal CT and a gastroesophageal junction adenocarcinoma was diagnosed. Surgical treatment was then performed with a limited lymphadenectomy due to adhesions. Pathology results were an IIIB stage stomach carcinoma. 

Discussion: Although the most common malignancies found among liver and renal transplanted populations are lymphoproliferative and skin tumors, there´s an increased incidence of gastric malignancies when compared to non-transplanted patients. The impact of overall medical costs related to malignancy in transplanted patients is high and close surveillance and early detection of such malignancies is important. 

Conclusion: Transplanted populations are at higher risk of developing neoplasm in different locations. An aggressive screening with early detection and treatment it´s crucial to avoid lethal outcomes.

Keywords: Transplant, Gastric Cancer, Immunotherapy

References

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Citation: Lourenço LG.., et al. “Advanced Gastric Cancer after Two Liver and One Renal Transplantation. Case Report”. EC Gastroenterology and Digestive System 7.3 (2020): 01-05.

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