Research Article
Volume 7 Issue 6 - 2020
Effect of Sustained Viral Response of Chronic Hepatitis C on Serum Vitamin D Level
Ayse Kefeli1* and Ayse Kevser Demir2
1Department of Gastroenterology, Faculty of Medicine, Tokat Gaziosmanpasa University, Turkey
2Department of Internal Medicine, Faculty of Medicine, Tokat Gaziosmanpasa University, Turkey
*Corresponding Author: Ayse Kefeli, Department of Gastroenterology, Faculty of Medicine, Tokat Gaziosmanpasa University, Turkey.
Received: April 20, 2020; Published: May 21, 2020




Abstract

Background: The aim of the study was to investigate the change in serum vitamin D levels in patients who achieved sustained viral response by treatment with DAA.

Material and Method: Between June 2016 and June 2018, 107 patients with chronic hepatitis C treated with direct-acting antivirals were included in this study. Pre-treatment, post-treatment and control groups were analyzed for serum vitamin D levels. The effect of sustained viral response of Chronic Hepatitis C on vitamin D levels was evaluated.

Results: The prevalence of vitamin D insufficiency (20 - 30 ng/mL) and deficiency (< 20 ng/mL) were 13% and 60.7% in patients with Chronic Hepatitis C, respectively. Considering patients with low serum vitamin D, the mean serum vitamin D level before treatment was 22.9 ± 19.9 ng/dl, whereas the mean serum vitamin D level after treatment was 25.3 ± 17.7 ng/dl and was statistically significant increased (p < 0.001).

Conclusion: The prevalence of vitamin D deficiency is high in patients with Chronic Hepatitis C. Vitamin D levels may increase with direct-acting antiviral treatment, particularly in patients with Vitamin D deficiency and insufficiency.

Keywords: Chronic Hepatitis C; Vitamin D; Direct Acting Antivirals

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Citation: Ayse Kefeli and Ayse Kevser Demir. “Effect of Sustained Viral Response of Chronic Hepatitis C on Serum Vitamin D Level”. EC Gastroenterology and Digestive System 7.6 (2020): 38-42.

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