Research Article
Volume 7 Issue 10 - 2020
C Reactive Protein: A Reliable Marker for Early Diagnosis of Anastomotic Leakage in Colorectal Surgery?
Viola Agustín Javier1, Nicolas Luis Avellaneda1*, Lasa Juan2, Olivera Pablo1, Oddi Ricardo2 and Carrie Augusto1
1General Surgery Department, Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno” (CEMIC), Galvan, Buenos Aires, Argentina
2Chief of General Surgery Department, Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno” (CEMIC), Galvan, Buenos Aires, Argentina
*Corresponding Author: Nicolas Luis Avellaneda, General Surgery Department, Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno” (CEMIC), Galvan, Buenos Aires, Argentina.
Received: August 14,, 2020; Published: September 10, 2020


Background: Anastomotic leakage (AL) related to colorectal surgery is associated with high morbidity and mortality. Predicting AL remains challenging but may improve outcomes significantly. Serum biomarkers, such as C reactive protein (CRP), white blood (WBC) count and platelets could be useful.

Aim: To evaluate the role of CRP, WBC and platelets in postoperative period of colorectal surgery with anastomosis as predictors of AL.

Methods: A prospective database including patients undergoing colorectal surgery was developed during a 16-month period. After applying exclusion criteria, 84 patients were eligible. In the postoperative period, daily blood samples were collected to determine CRP, WBC and platelet count until postoperative day 5 or until discharge.

Results: Eight patients developed AL (50% of which were major). An association between AL and high CRP was demonstrated on postoperative day 2 with a threshold of 223.7 mg/L. CRP presented an area under the receiver operator curve (AUROC) of 0.7993. White blood count (WBC) and platelet count did not demonstrate any significant difference between groups.

Conclusion: CRP is a useful serum biomarker for the early diagnosis of AL after colorectal surgery. Early recognition of AL may lead to better outcomes.

Keywords: PCR; Anastomosis; Leak; Marker; Colorectal; Surgery


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Citation: Nicolas Luis Avellaneda., et al. “C Reactive Protein: A Reliable Marker for Early Diagnosis of Anastomotic Leakage in Colorectal Surgery?”. EC Gastroenterology and Digestive System 7.10 (2020): 13-24.

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