Research Article
Volume 7 Issue 10 - 2020
Clinical Manifestations and Pathogenesis of Hepatic Damage in SARS-CoV-2 in Comparison to MERS-CoV and SARS-CoV
Jasndeep Kaler1*, Elsa Tabrez2, Azhar Hussain1,3, Shams Tabrez4, Sundus Nasim5 and Sohail Kumar5
1MD Candidate, Xavier University School of Medicine, Oranjestad, Aruba
2Medical Student, American University of Integrative Sciences, Barbados
3Doctoral Candidate of HealthCare Administration, Franklin University, Ohio, USA
4Assistant Professor of Medicine and Board-Certified Gastroenterology and Hepatology at University of Central Florida, Florida, USA
5MBBS, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
*Corresponding Author: Jasndeep Kaler, MD Candidate, Xavier University School of Medicine, Oranjestad, Aruba.
Received: August 28, 2020; Published: September 30, 2020




Abstract

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, its systemic manifestations continue to gain more focus. Recently, an association between n2019-CoV and hepatic damage has emerged. While there is no clearcut understanding of the viral mechanism causing hepatic and biliary injuries, the involvement of several different mechanisms is likely. Current hypotheses suggest that the liver presents with a high expression of ACE2 receptors, allowing the virus to penetrate the hepatocytes and the bile duct epithelial cells. The hepatic injury in n2019-CoV positive patients could also result from other reasons such as cytokine storm that leads to the systemic inflammatory response syndrome, administration of hepatotoxic drugs, such as acetaminophen and antivirals, and pre-existing liver diseases. Its resemblance to the injury caused by SARS-CoV and MERS-CoV is remarkable which could be attributed to the genetic makeup of these different types of coronaviruses. As research continues, there is a greater need to understand the full extent of the hepatic injury that occurs due to SARS-CoV-2 and the mechanism to minimize the damage. It is necessary to compare the disease at a biochemical and pathological level with both MERS-CoV and SARS-CoV; this article aims to do so.

Keywords: Hepatic Damage; SARS-CoV-2; Coronavirus; MERS-CoV; SARS-CoV

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Citation: Jasndeep Kale., et al. “Clinical Manifestations and Pathogenesis of Hepatic Damage in SARS-CoV-2 in Comparison to MERS-CoV and SARS-CoV”. EC Gastroenterology and Digestive System 7.10 (2020): 95-105.

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