Case Report
Volume 8 Issue 2 - 2021
Effect of First Spontaneous Bacterial Peritonitis Event on the Survival of Cirrhotic Patients with Ascites and Predictive Factors of Recurrence
Hanen Jaziri1*, Khaled Agar1, Khairi Dhouioui2, Mehdi Ksiaa1, Aya Hammami1, Nour Eleuch1, Ahlem Brahem1, Salem Ajmi1, Aida Ben Slama1 and Ali Jmaa1
1Gastroenterology Department, Sahloul Hospital, Sousse, Tunisia
2Surgery Department, Sahloul Hospital, Sousse, Tunisia
*Corresponding Author: Jaziri Hanen, Gastroenterology Department, Sahloul Hospital, Sousse, Tunisia.
Received:December 07,2020; Published: January 30, 2021


Spontaneous bacterial peritonitis (SBP) is a serious and frequent complication of cirrhosis. The aim of our study was to assess the predictive factors of recurrence and mortality after a first episode of SBP. We perform a retrospective monocentric study, in Gastroenterology department of Sahloul Hospital, Sousse-Tunisia. we include all patients with first SBP episode in a cirrhosis wich defined by the presence of more than 250 neutrophils/mm3 in ascitic fluid. Secondary peritonitis and positive culture of ascitic fluid and neutrophils < 250/mm3 were excluded from this study including 49 cirrhotic patients with first episode of SBP between January 2005 and December 2015.they were 32 men and 17 women, with a mean age of 58 years old. Virus B hepatitis was the most frequent etiology of cirrhosis (57%). Fever (69%) and abdominal (67%) were the most revealing symptoms of SBP. Thirty five patients were Child C cirrhosis. Renal impairment was observed in one third of patients. A germ was identified in ascitic fluid in 18% of cases. For treatment, Cefotaxime was prescribed in most cases (87%). 30-day mortality rate was 16%. The principle predictive factors of mortality were: sepsis, creatinine level > 120 micmol/l, Prothrombin time < 40% and hyperkalemia (> 5 mmol/l). Predictive factors of recurrence of SBP after first episode were: Absence of antibioprophylaxis and protein levels in ascitic fluid < 10 g/l. During the course of cirrhosis, 10% of patients developed hepatorenal syndrome and 24% had and hepatocellular carcinoma (HCC). Overall 5-year survival rate after first episode of SBP was 44%.

Keywords: Ascitic Fluid; Infection; Prognosis


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Citation: Hanen Jaziri., et al. “Effect of First Spontaneous Bacterial Peritonitis Event on the Survival of Cirrhotic Patients with Ascites and Predictive Factors of Recurrence”. EC Gastroenterology and Digestive System 8.2 (2021): 118-124.

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