Research Protocol
Volume 8 Issue 4 - 2021
Long-Term Response Rate of Endoscopic Mucosal Resection (EMR) as a Treatment of Superficial Oesophageal Neoplasia in a Spanish Referral Center
Guiomar Moral Villarejo1*, Aparicio M1, Esteban López-Jamar JM2, Ruiz de León A1, Vázquez M2, Mendoza JL1, Ventero A1, García Pravia L1, López G1 and Rey Díaz-Rubio E1
1Gastroenterology Department, Hospital Clínico San Carlos, Madrid, Spain
2Endoscopy Department, Hospital Clínico San Carlos, Madrid, Spain
*Corresponding Author: Guiomar Moral Villarejo, Doctor in Gastroenterology, Hepatology and Endoscopy, Hospital Clínico San Carlos, Madrid, Spain.
Received: February 19, 2021; Published: March 12, 2021




Abstract

Adenocarcinoma (ADC) that appears on oesophageal mucosal containing Barrett’ disease is a prevalent type of cancer in the esophagus. The actual follow-up for Barrett’s oesophagus have allowed to diagnose a greater proportion of superficial cancers. The aim of this work is to establish the long-term efficacy of Endoscopic Mucosal Resection (EMR) in this superficial neoplasms of the oesophagus, based on a large Spanish series. We present a group of 23 accumulated patients (6 cases of High-Grade Dysplasia, 15 of Adenocarcinoma and 2 of Epidermoid Oesophageal Carcinoma) in which EMR is performed. The EMR confirmed that 16 were superficial oesophageal cancers. The other seven patients were sent to surgery due to a greater submucosal invasion. From the total of 16 patients, 13 have obtained complete eradication of intestinal metaplasia (CEIM). We follow those patients for a median of 73 months (6 years), with an interquartile range of 33.5 - 86.5 months. From the patients who obtained CEIM, 9 have required associating other therapeutic procedures such as repeated EMR or Radiofrequency Ablation (RFA) sessions. The CEIM is obtained in 81% of the total of patients with a correct diagnosis of superficial endoscopic neoplasia treated with EMR, with or without the need for subsequent treatments. Therefore, endoscopy plays nowadays a relevant role in the management of superficial oesophageal cancer, allowing for screening, diagnosis, treatment and follow-up in most cases. The EMR followed, if needed, by subsequent treatments such as the ablation of the remaining Barrett’s esophagus is the current treatment recommendation for early ADC.

Keywords: Upper GI; Endoscopy; Barrett’s Oesophagus; Superficial Oesophageal Neoplasia; EMR

Citation: Guiomar Moral Villarejo., et al. “Long-Term Response Rate of Endoscopic Mucosal Resection (EMR) as a Treatment of Superficial Oesophageal Neoplasia in a Spanish Referral Center”. EC Gastroenterology and Digestive System 8.4 (202): 25-26.

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