Case Study
Volume 8 Issue 4 - 2021
Refractory Coeliac Disease (About 05 Cases)
G Bennani1,2*, A Jahid1,2, I Benelberhdadi1,2 and F Ajana1,2
1Department of Diseases of the Digestive System, Medicine C, CHU IBN SINA- Souissi Med University V, Rabat, Morocco
2Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco
*Corresponding Author: G Bennani, Department of Diseases of the Digestive System, Medicine C, CHU IBN SINA- Souissi Med University V and Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.
Received: July 11, 2020; Published: March 29, 2021


Refractory coeliac disease (RCD) is defined by persistent or recurrent malabsorptive symptoms and villous atrophy despite strict adherence to a gluten-free diet (GFD) for at least 6 - 12 months in the absence of other causes of non-responsive treated coeliac disease and overt malignancy. Symptoms are often severe and require additional therapeutic intervention besides a GFD. RCD can be classified as type 1 which usually improves after treatment with a combination of aggressive nutritional support, adherence to a GFD, and alternative pharmacological therapies. By contrast, clinical response to alternative therapies in RCD type 2 is less certain and the prognosis is poor. Severe complications such as ulcerative jejunitis and enteropathy-associated T cell lymphoma may occur in a subgroup of patients with RCD. The aim of this article is to describe the profile of patients with RCD, their management and their evolution in a series of 284 patients with celiac disease.

Keywords: Refractory Coeliac Disease; Gluten-Free Diet; Therapeutic Management


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Citation: G Bennani., et al. “Refractory Coeliac Disease (About 05 Cases)”. EC Gastroenterology and Digestive System 8.4 (2021): 99-103.

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