Case Series
Volume 8 Issue 4 - 2021
Upper Gastrointestinal Tract Schwannomas- Report of Three Cases and Literature Review
Kamran Mushtaq*, Manik Sharma, Muhammad ElBadri, Arsalan Ahmad and Saad Al Kaabi
Department of Gastroenterology, Hamad General Hospital, Doha, Qatar
*Corresponding Author: Kamran Mushtaq, Department of Gastroenterology, Hamad Medical Corporation, Doha, Qatar.
Received: March 23, 20211; Published: April 15, 2021




Abstract

Background: Schwannoma is a benign mesenchymal tumor arising from peripheral nerve sheath. Schwannoma can occur sporadically or as a part of hereditary syndromes like Neurofibromatosis. Schwannomas are rare tumors in the gastrointestinal tract, the stomach being the most common site. Esophageal Schwannoma is even rarer, with fewer than 90 cases reported.

Methods: We report 3 cases of upper GI schwannomas (Gastric-2 Esophageal-1). The average age of detection was 36 years, and two of them were males. The average size of the tumor at detection was about 2.5 cm. Two of them required laparoscopic resection, and one of them was treated endoscopically. Histopathology revealed strong S-100 positivity on immunohistochemistry, and all of them were of benign nature.

Conclusion: Schwannomas are clinically, endoscopically and radiologically difficult to distinguish from gastrointestinal stromal tumors (GIST). Distinguishing Schwannoma from GIST is important as the latter has malignant potential. Schwannomas have a good prognosis with an extremely low recurrence rate.

 

Keywords: Gastric Schwannoma; Esophageal Schwannoma; GIST; Submucosal Tumors; Endoscopic Ultrasound

References

  1. Rodriguez Fausto J., et al. “Pathology of Peripheral Nerve Sheath Tumors: Diagnostic Overview and Update on Selected Diagnostic Problems”. Acta Neuropathologica3 (2012): 295-319.
  2. Shelat Vishal G., et al. “Abdominal Schwannomas: Case Report With Literature Review”. International Surgery3 (2013): 214-218.
  3. Watanabe Takayoshi., et al. “Resection of an Esophageal Schwannoma with Thoracoscopic Surgery: A Case Report”. Surgical Case Reports 2 (2016).
  4. Kwon Mi Seon., et al. “Schwannomas of the Gastrointestinal Tract: Clinicopathological Features of 12 Cases Including a Case of Esophageal Tumor Compared with Those of Gastrointestinal Stromal Tumors and Leiomyomas of the Gastrointestinal Tract”. Pathology, Research and Practice9 (2002): 605-613.
  5. Wang Yu-Long., et al. “Schwannoma of the Cervical Esophagus: Report of 2 Cases and a Review of the Literature”. Ear, Nose, and Throat Journal9 (2015): E10-13.
  6. Yoon Jong Min., et al. “Endosonographic Features of Gastric Schwannoma: A Single Center Experience”. Clinical Endoscopy6 (2016): 548-554.
  7. Voltaggio Lysandra., et al. “Gastric Schwannoma – A Clinicopathologic Study Of 51 Cases And Critical Review Of The Literature”. Human Pathology5 (2012): 650-659.
  8. Yang Jia-Hua., et al. “Gastroduodenal Intussusception Due to Gastric Schwannoma Treated by Billroth II Distal Gastrectomy: One Case Report”. World Journal of Gastroenterology: WJG7 (2015): 2225-2228.
  9. Carroll Steven L. “Molecular Mechanisms Promoting the Pathogenesis of Schwann Cell Neoplasms”. Acta Neuropathologica3 (2012): 321-348.
  10. Wippold FJ., et al. “Neuropathology for the Neuroradiologist: Antoni A and Antoni B Tissue Patterns”. American Journal of Neuroradiology9 (2007): 1633-1638.
  11. Miettinen Markku and Jerzy Lasota. “Gastrointestinal Stromal Tumors (GISTs): Definition, Occurrence, Pathology, Differential Diagnosis and Molecular Genetics”. Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists1 (2003): 3-24.
  12. Gu Mi Jin and Joon Hyuk Choi. “Microcystic/Reticular Schwannoma of the Esophagus: The First Case Report and a Diagnostic Pitfall”. BMC Gastroenterology 14 (2014).
  13. Schulz Christian., et al. “Rare Neoplasia of the Stomach”. Gastrointestinal Tumors2 (2015): 52-60.
  14. Benz Matthias R., et al. “Quantitative F18-Fluorodeoxyglucose Positron Emission Tomography Accurately Characterizes Peripheral Nerve Sheath Tumors as Malignant or Benign”. Cancer2 (2010): 451-458.
  15. Nishida Toshirou., et al. “Submucosal Tumors: Comprehensive Guide for the Diagnosis and Therapy of Gastrointestinal Submucosal Tumors”. Digestive Endoscopy5 (2013): 479-489.
  16. Park Hyung-Chul., et al. “Endoscopic Ultrasonographic Characteristics of Gastric Schwannoma Distinguished from Gastrointestinal Stromal Tumor”. The Korean Journal of Gastroenterology1 (2015): 21.
  17. Tao Kaixiong., et al. “Clinicopathologic Features of Gastric Schwannoma”. Medicine45 (2015).
  18. Naus Peter J., et al. “Esophageal Schwannoma: First Report of Successful Management by Endoscopic Removal”. Gastrointestinal Endoscopy4 (2001): 520-522.
  19. Hong Xiafei., et al. “Benign Gastric Schwannoma: How Long Should We Follow Up to Monitor the Recurrence? A Case Report and Comprehensive Review of Literature of 137 Cases”. International Surgery4 (2015): 744-747.
  20. Takemura Masashi., et al. “Gastric Malignant Schwannoma Presenting with Upper Gastrointestinal Bleeding: A Case Report”. Journal of Medical Case Reports 6 (2012): 37.
  21. Wang Shaohua., et al. “Long-Term Survival in a Rare Case of Malignant Esophageal Schwannoma Cured by Surgical Excision”. The Annals of Thoracic Surgery 1 (2011): 357-358.
Citation: Kamran Mushtaq., et al. “Upper Gastrointestinal Tract Schwannomas- Report of Three Cases and Literature Review”. EC Gastroenterology and Digestive System 8.4 (2021): 22-29.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 21, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk