Case Report
Volume 8 Issue 5 - 2021
Successful Treatment of Eosinophilic Gastroenteritis with Anti-IgE Therapy
Abdulrahman Qatomah1*, Mohammad Saeedi2, Najla Sayes3 and Sultan Alandijani3
1Resident, Department of Internal Medicine, McGill University Healthcare Center, Montreal, Quebec, Canada
2Resident, Department of Internal Medicine, King Faisal Hospital and Research Center, Jeddah, KSA
3Consultant Allergy/Immunology, Department of Internal Medicine, King Faisal specialist Hospital and Research Center, Jeddah, KSA
*Corresponding Author: Abdulrahman Qatomah, Resident, Department of Internal Medicine, McGill University Healthcare Center, Montreal, Quebec, Canada.
Received: April 01, 2021; Published: April 23, 2021




Abstract

Eosinophilic gastroenteritis (EGE) is a rare chronic inflammatory disorder characterized by infiltration of different parts of the gastrointestinal (GI) tract with eosinophils producing variable clinical presentations.

Diagnosis is largely dependent on the histopathological findings in the appropriate clinical context and absence of other causes of eosinophilic infiltration such as inflammatory bowel diseases, parasitic infections, drugs and malignancies.

The mainstay of treatment is systemic steroid. However, several other immunomodulatory agents have been used as a second line therapy.

Omalizumab is an anti-IgE monoclonal antibody developed for treatment of severe uncontrolled bronchial asthma and urticarial, its’ efficacious utilization for treatment of EGE has been reported recently in the literature.

Herein, we report a case of 25-years-old male patient who presented with acute abdomen requiring surgery and bowel resection, he was found to have eosinophilic infiltration of the GI tract on subsequent workup, Other secondary causes of eosinophilic infiltration were ruled out.

A trial of Omalizumab was initiated after a long-term therapy of systemic steroids and multiple relapses of his abdominal pain upon tapering down his steroids dose, therapy with Omalizumab has resulted in a remarkable clinical response and sustained remission of his symptoms.

 

Keywords: Gastroenteritis; Anti-Ig; Omalizumab; Eosinophilic

References

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Citation: Abdulrahman Qatomah., et al. “Successful Treatment of Eosinophilic Gastroenteritis with Anti-IgE Therapy”. EC Gastroenterology and Digestive System 8.5 (2021): 62-65.

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