Research Article
Volume 8 Issue 8 - 2021
Local Injection of Anti-Cancer Drugs in an Experimental Model of Colorectal Cancer, a Novel Scenario to Treat Invasive Neoplasia
Vicente Lorenzo-Zúñiga1*, Ignacio Bon2, Napoleón de la Ossa3 and Ramón Bartolí2
1Endoscopy Unit, Hospital Universitari i Politècnic La Fe, Valencia, Spain
2Health Research Institute Germans Trias i Pujol (IGTP), Barcelona, Spain
3Pathological Department, Hospital Universitari General de Catalunya, Barcelona, Spain
*Corresponding Author: Vicente Lorenzo-Zúñiga, Endoscopy Unit, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Received: June 23, 2021; Published: July 17, 2021




Abstract

Purpose: Endoscopic resection of colorectal lesions significantly decreases the risk of colorectal cancer (CRC) incidence and death. Patients with invasive neoplasia or metastatic CRC have an evident poorer prognosis. Next step could be a more personalized treatment strategy, as a targeted therapy by direct injection of active substances in a selected lesion. The aim was to evaluate the efficacy of intratumoral injection of a drug-eluting platform (CoverGelâ) with different anti-cancer drugs in a rat model of azoxymethane (AOM)-induced CRC.

Methods: Experimental CRC was induced in 20 rats. Animals were randomized in five groups (four each): CoverGel + Aflibercept (AFL), CoverGel + Bevacizumab (BVZ), CoverGel + Cetuximab (CTX), CoverGel + Panitumumab (PNT) and CoverGel + Irinotecan (IRT). Endoscopic, histological and necrosis score (0-3 scale) test were performed during follow-up to evaluate clinical success.

Results: All animals developed invasive neoplasia (NICE 3, JNET 3), 7.2 mm as mean size (range 6 - 8). Intratumoral injection was feasible in all animals with no adverse events. AFL, an angiogenesis inhibitor agent, in comparison with the other medications (BVZ, CTX, PNT and IRT) obtained the best results: significantly reduction in tumor size (-30% vs. -10%, -3%, +2% and + 2%; p < 0.05, respectively) and significantly higher necrosis score (3 vs. 1, 0.3, 0 and 0; p < 0.05, respectively).

Conclusion: Angiogenesis inhibitors medications produced the higher cell necrosis and reduction in tumor size in an experimental model of CRC. Intratumoral injection of a drug-eluting platform could open a new way to manage invasive CRC.

Keywords: Colorectal Cancer; Drug-Eluting Platform; Intratumoral Injection; Experimental Model

References

  1. Zauber AG., et al. “Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths”. The New England Journal of Medicine8 (2012): 687-696.
  2. Gini A., et al. “Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review”. European Journal of Cancer 127 (2020): 224-235.
  3. National Cancer Institute; Surveillance, Epidemiology, and End Results Program”. Cancer stat facts: Colorectal Cancer (2019).
  4. Raju GS., et al. “Outcome of EMR as an alternative to surgery in patients with complex colon polyps”. Gastrointestinal Endoscopy2 (2016): 315-325.
  5. Peery AF., et al. “Morbidity and mortality after surgery for nonmalignant colorectal polyps”. Gastrointestinal Endoscopy1 (2018): 243-250.
  6. Rex DK., et al. “Colorectal endoscopic submucosal dissection in the United States: why do we hear so much about it and do so little of it?” Gastrointestinal Endoscopy3 (2017): 554-558.
  7. Jang SR., et al. “Cost-effectiveness Evaluation of Targeted Surgical and Endoscopic Therapies for Early Colorectal Adenocarcinoma Based on Biomarker Profiles”. JAMA Netw Open3 (2020): e1919963.
  8. Bon I., et al. “Development and characterization of a new endoscopic drug eluting platform with proven efficacy in acute and chronic experimental colitis”. Frontiers in Medicine (2020).
  9. Perse M and Cerar A. “Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogénesis in rats”. Journal of Biomedicine and Biotechnology (2011): 474964.
  10. Lorenzo-Zúñiga V., et al. “Local injection of infliximab in symptomatic isolated mucosal lesions: A novel scenario for endoscopic therapy?” Inflammatory Bowel Diseases4 (2013): E59-61.
  11. Bird RP. “Role of aberrant crypt foci in understanding the pathogenesis of colon cancer”. Cancer Letters1 (1995): 55-71.
  12. Tanaka T. “Colorectal carcinogenesis: review of human and experimental animal studies”. Journal of Carcinogenesis 8 (2009): 5.
  13. Hashiguchi Y., et al. “Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer”. The International Journal of Clinical Oncology 25 (2020): 1-42.
  14. Hanahan D and Weinberg RA. “Hallmarks of cancer: the next generation”. Cell 144 (2011): 646-674.
  15. Seeber A., et al. “Anti-angiogenics: Their value in colorectal cancer therapy”. Oncology Research and Treatment4 (2018): 188-193.
Citation: Vicente Lorenzo-Zúñiga., et al. “Local Injection of Anti-Cancer Drugs in an Experimental Model of Colorectal Cancer, a Novel Scenario to Treat Invasive Neoplasia” EC Gastroenterology and Digestive System 8.8 (2021): 21-26.

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