Abstract
Introduction: Esophageal Cancer is a global concern due to its high incidence and persistent high mortality rates. At the time of diagnosis, more than 50% of patients have unresectable disease or distant metastasis. Sarcopenia is considered an independent risk factor for prognosis. Thus, it is relevant to assess the presence of sarcopenia and see if it is associated with decreased survival.
Objectives: To identify a possible correlation between the presence of sarcopenia and the survival of patients with lymph nodes metastasis of EC and to evaluate the prevalence of sarcopenia in these patients.
Methodology: Sample of 26 patients with histological diagnosis of Esophageal Adenocarcinoma or Squamous Cell Carcinoma with lymph nodes metastasis, submitted to surgical ressection. The patient’s Muscle Mass Index (SMI) was measured using lumbar CT, at L3 level, in a single axial section, using appropriate software. The association of qualitative variables with the presence or absence of sarcopenia was assessed using the Pearson´s Chi-Square Test (χ2) or Fisher’s Exact Test. For continuous variables the T test was used. Survival curves were determined for overall survival and disease-free survival using Kaplan-Meier method and the log-rank test. A Cox regression was also performed.
Results: The average age of patients was 64 years, the majority being male (88,5%). 9 (34,6%) patients had sarcopenia. Sarcopenia was not significantly associated with a decrease in DFS (p = 0,1,75) or a decrease in OS (p = 0,113). Staging was associated with lower overall survival (p = 0,033). There was not significant association between sarcopenia and clinical anatomopathological factors.
Conclusion: Sarcopenia has not been shown to have an impact on the survival of patients with esophageal lymph nodes metastasis.
Keywords: Esophageal Cancer; Lymph Node Metastasis; Sarcopenia; Survival
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