Research Article
Volume 8 Issue 10 - 2021
Impact of Sarcopenia on the Survival of Patients with Lymph Nodes Metastasis of Esophageal Cancer
Joana Maria da Silva Costa1, Ana Maria Ferreira Peixoto Pereira2* and Sandra F Martins3,4,5
1School of Medicine, University of Minho, Braga, Portugal
2General Surgery Resident, Braga Hospital, Braga, Portugal
3Coloproctology Unit, Department of General Surgery, Hospital de Braga, Braga, Portugal
4Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
4Life and Health Sciences Research Institute (ICVS)/3B’s-PT Government Associate Laboratory, Braga/Guimarães, Braga, Portugal
*Corresponding Author: Ana Maria Ferreira Peixoto Pereira, General Surgery Resident, Braga Hospital, 4710-243 Braga, Portugal.
Received: July 02, 2021; Published: September 21, 2021




Abstract

Introduction: Esophageal Cancer is a global concern due to its high incidence and persistent high mortality rates. At the time of diagnosis, more than 50% of patients have unresectable disease or distant metastasis. Sarcopenia is considered an independent risk factor for prognosis. Thus, it is relevant to assess the presence of sarcopenia and see if it is associated with decreased survival.

Objectives: To identify a possible correlation between the presence of sarcopenia and the survival of patients with lymph nodes metastasis of EC and to evaluate the prevalence of sarcopenia in these patients.

Methodology: Sample of 26 patients with histological diagnosis of Esophageal Adenocarcinoma or Squamous Cell Carcinoma with lymph nodes metastasis, submitted to surgical ressection. The patient’s Muscle Mass Index (SMI) was measured using lumbar CT, at L3 level, in a single axial section, using appropriate software. The association of qualitative variables with the presence or absence of sarcopenia was assessed using the Pearson´s Chi-Square Test (χ2) or Fisher’s Exact Test. For continuous variables the T test was used. Survival curves were determined for overall survival and disease-free survival using Kaplan-Meier method and the log-rank test. A Cox regression was also performed.

Results: The average age of patients was 64 years, the majority being male (88,5%). 9 (34,6%) patients had sarcopenia. Sarcopenia was not significantly associated with a decrease in DFS (p = 0,1,75) or a decrease in OS (p = 0,113). Staging was associated with lower overall survival (p = 0,033). There was not significant association between sarcopenia and clinical anatomopathological factors.

Conclusion: Sarcopenia has not been shown to have an impact on the survival of patients with esophageal lymph nodes metastasis.

Keywords: Esophageal Cancer; Lymph Node Metastasis; Sarcopenia; Survival

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Citation: Ana Maria Ferreira Peixoto Pereira., et al. “Impact of Sarcopenia on the Survival of Patients with Lymph Nodes Metastasis of Esophageal Cancer”. EC Gastroenterology and Digestive System 8.10 (2021): 46-59.

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