Review Article
Volume 8 Issue 10 - 2021
Oral Microbiome and Digestive Diseases
Carlos Castañeda Guillot1,2*
1Emeritus Professor, Faculty of Medicine, Autonomous Regional University of Los Andes, Ambato, Ecuador
2Consulting Professor, Senior Research, Medical Faculty Calixto Garcia, Medical University of La Habana, Cuba
*Corresponding Author: Carlos Castañeda Guillot, Emeritus Professor, Faculty of Medicine, Autonomous Regional University of Los Andes, Ambato, Ecuador.
Received: August 04, 2021; Published: September 28, 2021




Abstract

The implications of the oral microbial community with the intestinal microbiota and the participation in inflammatory bowel diseases and colorectal and pancreatic cancer due to the effect of dysbiosis and pathogenic bacteria of the oral cavity are reviewed. To update the knowledge on the link between the oral microbiota and the repercussion of dysbiosis caused by pathogenic bacteria in chronic digestive diseases kas been the reason for the review. There was evidence of a relationship between oral and intestinal microbiota, participation of the oral-intestinal axis, role of dysbiosis in the oral cavity and pathogens such as Porphyromonas gingivalis, Klebsiella pneumoniae and Fusobacterium nucleatum in inflammatory bowel disease and digestive cancer. Recent advances on oral-intestinal microbiota links, influence of dysbiosis and pathogenic oral bacteria in the pathogenesis of inflammatory bowel diseases and in colorectal and pancreatic cancer, and the value of oral cavity hygiene in health were reviewed.

Keywords: Microbiomes; Oral Microbiota; Intestinal Microbiota; Dysbiosis; Oral Health; Digestive Diseases; Colorectal Cancer and Pancreatic Cancer

References

  1. Kane SH. “The effects of oral health on systemic health”. General Dentistry6 (2017): 30-34.
  2. Papapanou PN and Susin C. “Periodontitis epidemiology: is periodontitis under-recognized, over-diagnosed, or both?” Periodontology 75 (2017): 45-51.
  3. Gobin R., et al. “Periodontal Diseases and the Risk of Metabolic Syndrome: An Updated Systematic Review and Meta-Analysis”. Frontiers Endocrinology (2020).
  4. Verma D., et al. “Inaighta into the human oral microbiome”. Archives of Microbiology4 (2018): 525-540.
  5. Sharma N., et al. “Oral microbiome and health”. AIMS Microbiology1 (2018): 42-66.
  6. Castañeda C. “Microbiota intestinal”. Capítulo 2. En: Microbiota intestinal humana y sus desafíos. Quito.; Ecuador (2020): 11-27.
  7. Bartlett A., et al. “The Link between Oral and Gut Microbiota in Inflammatory Bowel Disease and a Synopsis of Potential Salivary Biomarkers”. Applied Science 10 (2020): 6421.
  8. Vieira S., et al. “Quantitative microbiome profiling disentangles inflammation and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses”. Nature Microbiology 4 (2019): 1826-1831.
  9. Tulkens J. “Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction”. Gut 1 (2020): 191-193.
  10. Nowicki EM., et al. “Microbiota and metatranscriptome changes accompanying the onset of gingivitis”. mBio 2 (2018): e00575-00518.
  11. Jepsen S., et al. “Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of work group 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions”. Journal Periodontology 1 (2018): S237-S248.
  12. Seo Y., et al. “Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium”. Laboratory Animal Research 35 (2019): 26.
  13. Rowland I., et al. “Gut microbiota functional: metabolism and nutrients and other food components”. European Journal Nutrition1 (2018): 1-24.
  14. Richard M amd Sokol H. “The gut microbiota: insight into analysis environmental interactions and role in gastrointestinal diseases”. Nature Reviews Gastroenterology and Hepatology 16 (2018): 331-345.
  15. Caselli F., et al. “Defining the oral microbiome by whole-genome sequence and resistome analysis the complexity of the healthy picture”. BMC Microbiology1 (2020): 120.
  16. Gao L., et al. “Oral microbiomes: more and more importance in oral cavity and whole body”. Protein Cell 9 (2018): 488-500.
  17. Castañeda C. “Microbiota intestinal y salud infantile”. Revista Cubana Pediatria1 (2017).
  18. Kastl AJ., et al. “The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions”. Cell Molecular Gastroenterology Hepatology 9 (2020): 33-45.
  19. Bartlett A., et al. “The Link between Oral and Gut Microbiota in Inflammatory Bowel Disease and a Synopsis of Potential Salivary Biomarkers”. Applied Science 10 (2020): 6421.
  20. Flemer RB., et al. “The oral microbiota in colorectal cancer is distinctive and predictive”. Gut8 (2014): 1454-1463.
  21. Zhang Y., et al. “Oral microbiota and gastrointestinal cancer”. Dovepress 12 (2019): 4721-4728.
  22. Eriksson K., et al. “Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis”. Journal Clinical Medicine5 (2019): 630.
  23. Bryan NS., et al. “Oral microbiome and nitric oxide: the missing link in the management of blood pressure”. Current Hypertension Reports4 (2017): 33.
  24. Cobb CM., et al. “The oral microbiome and adverse pregnancy outcomes”. International Journal of Women's Health 9 (2017): 551-559.
  25. Caruso R., et al. “Host–microbiota interactions in inflammatory bowel disease”. Nature Reviews Immunology7 (2020): 411-426.
  26. Park SY., et al. “Oral-Gut Microbiome Axis in Gastrointestinal Disease and Cancer”. Cancers9 (2021): 21-24.
  27. Kitamoto S., et al. “The bacterial connection between the Oral Cavity and the Gut Diseases”. Journal Dental Research9 (2020): 1121-1129.
  28. Agossa K., et al. “Odontal manifestations of inflammatory bowel disease: emerging epidemiologic and biologic evidence”. Journal Periodontology Research 52 (2017): 313-324.
  29. Dickson I. “Oral bacteria: A cause of IBD?” Review. Gastroenterology and Hepatology 15 (2018): 5.
  30. Rautava J., et al. “Oral microbiome composition changes in mouse models of colitis”. Journal Gastroenterology Hepatology 30 (2015): 521-527.
  31. Said H., et al. “Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers”. DNA Research1 (2014): 15-25.
  32. Bray F., et al. “Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries”. CA Cancer Journal Clinic6 (2018): 394-424.
  33. Ferlay J., et al. “Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods”. International Journal Cancer8 (2018)): 1941-1953.
  34. Le Bars P., et al. “The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract”. Cancer Journal Microbiology6 (2017): 475-492.
  35. Irfan M., et al. “The oral microbiome and cancer”. Frontiers in Immunology 11 (2020): 591088.
  36. Piscione M., et al. “Eradication of Helicobacter pylori and gastric cancer: A controversial relationship”. Frontiers in Microbiology 12 (2021): 730852.
  37. Siegel R., et al. “Cancer Statistics 2020”. Ca: A Cancer Journal for Clinicians1 (2020): 7-30.
  38. La Rosa GRM., et al. “Association of oral dysbiosis with oral cancer development”. Oncology Letters4 (2020): 3045-3058.
  39. Wei AL., et al. “Oral microbiome and pancreatic cancer”. World Journal Gastroenterology48 (2020): 7679-7692.
  40. Binder-Gallimidi A., et al. “Periodontal pathogen Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model”. Oncotarget26 (2015): 22613-22623.
  41. Olsen I., et al. “Possible role of Porphyromonas gingivalis in orodigestive cancers”. Journal Oral Microbiology 1 (2019): 1563410.
  42. Zhou Y and Lui GH. “Porphyromonas gingivalis and digestive system cancers”. World Journal Clinical Cases 7 (2019): 819-829.
  43. Gao S., et al. “Presence of Porphyromonas gingivalis in esophagus and its association with the clínico pathological characteristics and survival in patients with esophageal cancer”. Infect Agent Cancer 11 (2016): 3.
  44. Koliarakis I., et al. “Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer”. International Journal Molecular Science 17 (2019): 4146.
  45. Pignateli P., et al. “The Potential of Colonic Tumor Tissue Fusobacterium nucleatum to Predict Staging and Its Interplay with Oral Abundance in Colon Cancer Patients”. Cancers 5 (2021): 1032.
  46. Komiya Y., et al. “Patients with colorectal cancer have identical strains of Fusobacterium nucleatum in their colorectal cancer and oral cavity”. Gut 7 (2019):1335-1337.
  47. Chung M., et al. “Comparisons of oral intestinal and pancreatic bacterial microbiomes in patients with pancreatic cancer and other gastrointestinal diseases”. Journal Oral Microbiology 1 (2021): 1887680.
  48. Mohammed H., et al. “Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature”. Biomedicines 4 (2018): 115.
  49. Fan X., et al. “Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study”. Gut1 (2019): 120-127.
  50. Öğrendik M. “Periodontal pathogens in the etiology of pancreatic cancer”. Gastrointestinal Tumors 3-4 (2017): 125-127.
  51. Ahn J., et al. “Periodontal diseases, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality”. Carcinogenesis5 (2012) 1055-1058.
  52. Olsen I., et al. “Porphyromonas gingivalis suppresses adaptative immunity, periodontitis, atherosclerosis Alzheimer’s disease”. Journal Oral Microbiology 1 (2016): 33029.
  53. Erdman SE and Poutahidis T. “Gut microbiota modulate host immune cells in cancer development and growth”. Free Radical Biological Medicine 105 (2017): 28-34.
Citation: Carlos Castañeda Guillot. “Oral Microbiome and Digestive Diseases”. EC Gastroenterology and Digestive System 8.10 (2021): 85-92.

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