Research Article
Volume 8 Issue 11 - 2021
Pathogenetic Role of Insulin-Like Growth Factor (IGF-I) in Ulcerative Colitis

VV Pavlenko1* and AF Pavlenko2

1Professor, Head of Department for Propaedeutics of Internal Diseases, Stavropol State Medical University, Ministry of Healthcare, Russian Federation, Stavropol, Russia
2Associate Professor, Department of Therapy with a Course in Dietetics, Stavropol State Medical University, Ministry of Healthcare, Russian Federation, Stavropol, Russia
*Corresponding Author: : VV Pavlenko, Professor, Head of Department for Propaedeutics of Internal Diseases, Stavropol State Medical University, Ministry of Healthcare, Russian Federation, Stavropol, Russia.
Received: September 09, 2021; Published: October 29, 2021




Abstract

Aim of Study: Identifying the role IGF-I in ulcerative colitis (UC) pathogenesis.

Materials and Methods: 63 patients were examined who featured various UC severity and endoscopic (Mayo index) activity in the treatment dynamics. The levels of IGF-I in peripheral blood and those of TNF-a, IL-10 in mononuclears under spontaneous and lipopolysaccharide-stimulated conditions were identified with EIA. The inflammation intensity in the colon mucosa (CM) relied on the method by Avtandilov G. G. Implying the calculation of the inflammatory infiltrate (%) in the mucous membrane’s own plate. The control group included 20 healthy volunteers. The statistical processing of the obtained data was carried out using SPSS 13.0 software.

Results: The periods of exacerbating ulcerative colitis revealed a lower content of IGF-I in peripheral blood, whereas the synthesis of TNF-a and IL-10 proved to be increased. The IGF-I content in the serum showed an inverse dependence on UC severity as well as on the degree of inflammatory reaction in the CM and the production of TNF-α by MNCs, while there was a direct dependence on IL-10 production. The clinical remission of UC developed along with an increase in IGF-I production, a decrease in TNF-α synthesis, and normalization of IL-10 production.

Conclusion: During the clinical remission of UC, the synthesis of TNF-α decreases naturally, with the production of IL-10 by MNCs normalizes, and the IGF-I growth factor production increases, which ensures regenerative activity of the intestinal mucosa epithelium through this period of the disease.

Keywords: Insulin-Like Growth Factor; Tumor Necrosis Factor-Alpha; Cytokines; Ulcerative Colitis; Inflammation

References

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Citation: VV Pavlenko and AF Pavlenko. “Pathogenetic Role of Insulin-Like Growth Factor (IGF-I) in Ulcerative Colitis”. EC Gastroenterology and Digestive System 8.11 (2021): 102-107.

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